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AP-1 dependent changes in chromatin accessibility in resistant basal cell carcinoma cell line

ABSTRACT: AP-1 dependent changes in chromatin accessibility in resistant basal cell carcinoma cell line

PROVIDER: PRJNA658994 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR12508237_1.fastq.gz	Fastqsanger.gz
	SRR12508237_2.fastq.gz	Fastqsanger.gz
	SRR12508238_1.fastq.gz	Fastqsanger.gz
	SRR12508238_2.fastq.gz	Fastqsanger.gz
	SRR12508239_1.fastq.gz	Fastqsanger.gz

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AP-1 dependent changes in chromatin accessibility in resistant basal cell carcinoma cell line

Project description:Tumor heterogeneity and lack of knowledge about resistant cell states remain a significant barrier to effective targeted cancer therapies. Basal cell carcinomas (BCCs) uniformly depend on Hedgehog (Hh)/Gli signaling for cell growth. We previously identified a nuclear myocardin-related transcription factor (nMRTF) resistance pathway that amplifies Gli1 activity, but nMRTF cell state and key factors driving its accumulation remain unknown. We have determined that AP-1 transcription factor activity is essential to maintain MRTF activation. Here, we treat a murine BCC cell line with small molecule AP-1 inhibitor and analyze chromatin accessibility profiles.

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