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Next Generation Sequencing Facilitates Quantitative Analysis of Control and rhCYGB treated liver and HHSteC transcriptomes

ABSTRACT: Next Generation Sequencing Facilitates Quantitative Analysis of Control and rhCYGB treated liver and HHSteC transcriptomes

PROVIDER: PRJNA659008 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR12508417_1.fastq.gz	Fastqsanger.gz
	SRR12508417_2.fastq.gz	Fastqsanger.gz
	SRR12508418_1.fastq.gz	Fastqsanger.gz
	SRR12508418_2.fastq.gz	Fastqsanger.gz
	SRR12508419_1.fastq.gz	Fastqsanger.gz

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Next Generation Sequencing Facilitates Quantitative Analysis of Control and rhCYGB treated liver transcriptomes [TAA]

Project description:Purpose: The goal of this study is to investigate the effect of recombinant human Cytoglobin (rhCYGB) on liver fibrosis induced by TAA in mice. Method: mRNA profiles of liver tissues from TAA-control mice and TAA-rhCYGB treated mice were generated by deep sequencing. Results: The RNA-seq data confirmed that extracellular matrix-encoding genes and fibrosis-related genes were down-regulated by the rhCYGB treatment.

2020-08-25 | GSE156777 | GEO

Next Generation Sequencing Facilitates Quantitative Analysis of Control and rhCYGB treated liver transcriptomes [TAA]

Project description:Next Generation Sequencing Facilitates Quantitative Analysis of Control and rhCYGB treated liver transcriptomes [TAA]

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Next Generation Sequencing Facilitates Quantitative Analysis of Control and rhCYGB treated liver transcriptomes [DDC]

Project description:Next Generation Sequencing Facilitates Quantitative Analysis of Control and rhCYGB treated liver transcriptomes [DDC]

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Next Generation Sequencing Facilitates Quantitative Analysis of Control and rhCYGB treated liver transcriptomes [DDC]

Project description:Purpose: The goal of this study is to investigate the effect of recombinant human Cytoglobin (rhCYGB) on liver fibrosis induced by DDC diet in mice. Method: mRNA profiles of liver tissue of DDC-control mice and liver tissue of DDC-rhCYGB treated mice treated were generated by deep sequencing. Results: The RNA-seq data confirmed that extracellular matrix-encoding genes and fibrosis-related genes were down-regulated by the His-CYGB treatment.

2020-08-25 | GSE156778 | GEO

Next Generation Sequencing Facilitates Quantitative Analysis of HHSteCs and HHSteC treated rhCYGB [HSC]

Project description:Next Generation Sequencing Facilitates Quantitative Analysis of HHSteCs and HHSteC treated rhCYGB [HSC]

| PRJNA659013 | ENA

Next Generation Sequencing Facilitates Quantitative Analysis of HHSteCs and HHSteC treated rhCYGB [HSC]

Project description:Purpose: Hepatic stellate cells (HSCs) plays an important role in liver fibrosis. Recombinant human Cytoglobin (rhCYGB) can inhibit the activation of HSCs. The goal of this study is to investigate the rhCYGB targeted signalling pathways regulating the activation of HSCs. Method: mRNA profiles of HHSteCs control and HHSteCs treated with rhCYGB (80 µg/ml, for 48 hour) were generated by deep sequencing. Results: The RNA-seq data confirmed that extracellular matrix-encoding genes and fibrosis-related genes were down-regulated by the His-CYGB treatment. The top of up-regulated genes following His-CYGB treatment were interferon (IFN)-stimulated genes (ISGs), implying IFN signaling in His-CYGB treatment.

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