Project description:Building on GWAS for NHLBI-diseases: the U.S. CHARGE consortium (CHARGE-S): Subheading: targeted, exome and whole genome sequencing in the NHLBI ARIC, CHS and FHS cohorts
Project description:NHLBI Candidate-Gene Association Resource (CARe), gene discovery and characterization through candidate gene analyses and African American GWAS in NHLBI cohorts
Project description:<p>The EVE Asthma Genetics Consortium comprises U.S. investigators who have conducted genome-wide association studies (GWAS) of asthma; the main objective is to combine results of individual studies to increase the overall power to identify loci for asthma and asthma-associated traits. The consortium includes investigators at 9 U.S. institutions with GWAS results for >10,000 individuals representing European American, African American, African Caribbean, U.S. Hispanic, and Mexican populations and includes the following studies: <ul> <li>The Study of Asthma Phenotypes and Pharmacogenomic Interactions by Race-Ethnicity (SAPPHIRE)</li> <li>The Genetic Research on Asthma in the African Diaspora (GRAAD) Study</li> <li>The Genetics of Asthma in Latino Americans (GALA 1) Study</li> <li>The Childhood Asthma Management Program (CAMP)</li> <li>The Childhood Asthma Research and Education (CARE) Network</li> <li>The Children's Health Study (CHS)</li> <li>Mexico City Childhood Asthma Study (MCCAS)</li> <li>The Chicago Asthma Genetics Study (CAG)*</li> <li>The National Heart, Lung, and Blood Institute Collaborative Studies of the Genetics of Asthma (CSGA)*</li> <li>The Severe Asthma Research Program (SARP)*</li> </ul> (*CAG, CSGA, and SARP are part of the NHLBI-supported SNP Typing for Association with Multiple Phenotypes from Existing Epidemiologic Data (STAMPEED) consortium.) </p> <p>For the GWAS, we developed a common set of >1 million genotyped and imputed SNPs from the EVE Asthma Genetics Consortium to be tested for association with asthma and associated phenotypes in all samples and combined p-values for a grand meta-analysis for asthma gene discovery. A subset of 296 individuals representing African American, European American, and Latino ancestry were selected for whole genome sequencing.</p> <p>The broad goals of this project were to characterize the genetic architecture of asthma and associated quantitative phenotypes (e.g., lung function, total serum IgE) in ethnically diverse populations from the U.S., Mexico, Puerto Rico, and Barbados.</p>
