Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

RNAseq analysis of blood from respiratory viruses-infected patients and healthy controls

ABSTRACT: RNAseq analysis of blood from respiratory viruses-infected patients and healthy controls

PROVIDER: PRJNA660611 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR12561100_1.fastq.gz	Fastqsanger.gz
	SRR12561100_2.fastq.gz	Fastqsanger.gz
	SRR12561200_1.fastq.gz	Fastqsanger.gz
	SRR12561200_2.fastq.gz	Fastqsanger.gz
	SRR12561101_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 374

Similar Datasets

RNAseq analysis of blood from respiratory viruses-infected patients and healthy controls

Project description:The objective of this study was to understand the shared and unique elements of the host transcriptional response to different viral pathogens. We identified 162 subjects in the US and Sri Lanka with infections due to influenza, enterovirus/rhinovirus, human metapneumovirus, dengue virus, cytomegalovirus, Epstein Barr Virus, or adenovirus. Our dataset allowed us to identify common pathways at the molecular level as well as virus-specific differences in the host immune response. Conserved elements of the host response to these viral infections high-lighted the importance of interferon pathway activation. However, the magnitude of the re-sponses varied between pathogens. We also identified virus-specific responses to influenza, enterovirus/rhinovirus, and dengue infections.

2021-10-07 | GSE157240 | GEO

Respiratory viruses

Project description:Sequence hybridisation for respiratory viruses using the Twist Bioscience Respiratory panel

| PRJEB62137 | ENA

respiratory viruses

Project description:respiratory viruses in human nasal-throat swabs Raw sequence reads

| PRJNA639353 | ENA

RNAseq analysis of blood from influenza infected patients and healthy controls

Project description:Gene expression changes in the blood was studied by RNAseq Results: Strong differential host reponse after infection with influenza virus compared to healthy controls project SIG_2020

2024-07-30 | GSE196350 | GEO

RNAseq analysis of blood from influenza infected patients and healthy controls-SIG2019

Project description:Gene expression changes in the blood was studied by RNAseq; project SIG-2019 Results: Strong differential host reponse after infection with influenza virus compared to healthy controls

2024-07-30 | GSE155635 | GEO

A CXCL8 Signaling Axis Enables Susceptibility to Infection by Human Respiratory Viruses

Project description:Respiratory viruses pose an ongoing threat to human health, with excessive cytokine secretion playing a critical role in severe illness and mortality. However, the complex relationship between cytokine secretion and viral infection remains poorly understood. Here, we have unraveled the role of cxcl8 as an early response gene to respiratory EV-D68 infection. The upregulation of CXCL8 by viral infection is found to be crucial for EV-D68 replication. Importantly, silencing CXCL8 or its receptors, CXCR1/2, significantly impedes EV-D68 replication. Upon recognition of CXCL8 by CXCR1/2, the MAPK pathway is activated, facilitating the translocation of the essential host cofactor hnRNP K from the nucleus to the cytoplasm. This translocation enhances the recognition of viral RNA by hnRNP K in the cytoplasm, promoting the functionality of the 5’UTR region in the viral genome. Interestingly, the VP4 structural protein of EV-D68 contains a mimic motif of human immunoreceptor tyrosine-based activation motif (ITAM) that interacts with syk and triggers the PI3K/AKT signaling pathway, resulting in elevated CXCL8 gene expression for viral replication. Moreover, our investigations reveal the conservation and significance of the CXCL8 signaling pathway across various prominent human respiratory viruses, including SARS-CoV-2, influenza, and rhinovirus. In summary, our findings unveil a paradigmatic mechanism through which respiratory viruses exploit cytokine-mediated intercellular communication to transmit signals that optimize viral replication. This deepens our understanding of the shared evolutionary strategies employed by respiratory viruses and opens up new avenues for the development of broad-spectrum antiviral drugs targeting respiratory pathogens.

2024-11-22 | GSE273371 | GEO

LC-MS/MS Analysis of Respiratory Viruses

Project description:Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and other respiratory viruses -Coronavirus OC43, Coronavirus 229E, Influenza A/H1N1, Influenza A/H3N2, Influenza B, Respiratory Syncytial Virus RSV A and RSV B - were analysed by bottom-up proteomics of viral cultures. High coverage of viral proteins was acheived after culturing in serum-free conditions when compared to cultures grown using standard conditions including 2% fetal bovine serum.

2022-10-13 | PXD028562 | Pride

RNAseq analysis of blood from influenza infected patients and healthy controls, project SIG_2022

Project description:Goals: Study responses in peripheral blood of patients infected with influenza virus and compare to healthy control. Results: Strong differential host reponse after infection was observed.

2024-07-30 | GSE213168 | GEO

RNAseq analysis of blood from influenza infected patients and healthy controls SIG-2018

Project description:Gene expression changes in the blood was studied by RNAseq; project SIG-2018 Results: Strong differential host reponse after infection with influenza virus compared to healthy controls

2024-07-30 | GSE158592 | GEO

Host responses that correlate with respiratory droplet transmission of swine-origin influenza viruses in ferrets.

Project description:The determinants of influenza transmission remain poorly understood. Swine influenza viruses preferentially attach to receptors found in the upper airways; however, most swine influenza viruses fail to transmit efficiently from swine to humans, and from human-to-human. The pandemic 2009 H1N1 (H1N1pdm) virus was a rare exception of a swine virus that acquired efficient transmissibility from human-to-human, and is reflected in efficient respiratory droplet transmission in ferrets. We hypothesize that virus-induced host responses in the upper airways correlate with airborne transmission in ferrets. To address this question, we used the H1N1pdm virus and swine influenza A/swine/Hong Kong/201/2010 (HK201) virus that has comparable titre in the ferret nasopharynx, but it exhibits differential transmissibility in ferrets via respiratory droplet route. We performed a transcriptomic analysis of tissues from the upper and lower respiratory tract from ferrets infected with either H1N1pdm or HK201 viruses using ferret-specific Agilent oligonucleotide arrays. We found differences in the kinetics of the innate immune response elicited by these two viruses that varied across tissues.

2017-03-31 | GSE79282 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data