Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Derivation of endometrial gland organoids from term placenta

ABSTRACT: Derivation of endometrial gland organoids from term placenta

PROVIDER: PRJNA661086 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR12575639.fastq.gz	Fastqsanger.gz
	SRR12575640.fastq.gz	Fastqsanger.gz
	SRR12575641.fastq.gz	Fastqsanger.gz
	SRR12575642.fastq.gz	Fastqsanger.gz
	SRR12575643.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 10

Similar Datasets

Derivation of endometrial gland organoids from term placenta

Project description:A limitation of current methods for the generation of endometrial gland organoids is their reliance on decidua isolated from endometrial biopsies or elective abortion. Here we report the establishment of endometrial gland organoids from decidua isolated from term placental membranes. These organoids express typical markers of glandular epithelia such as E-cadherin, Laminin and Cytokeratin 7, and can be propagated in cell culture through multiple passages. Additionally, we identified potential survival factors for the co-culture of organoids and endometrial stromal fibroblasts. These modifications facilitate the generation of patient-specific endometrial gland organoids with known pregnancy outcomes.

2020-09-03 | GSE157380 | GEO

Endometrial gland impacts on stromal cell decidualization

Project description:Uterine glands and, by inference, their secretions impact uterine receptivity, blastocyst implantation, stromal cell decidualization, and placental development. Changes in gland function across the menstrual cycle are impacted by steroid hormones, estrogen and progesterone, as well as stroma-derived factors. Using an endometrial epithelial organoid (EEO) system, transcriptome and proteome analyses identified distinct responses of the EEO to steroid hormones and prostaglandin E2 (PGE2). Notably, steroid hormones and PGE2 modulated the basolateral secretion of EEO proteins, where cystatin C (CST3) was significantly increased by progesterone and PGE2. CST3 treatment of decidualizing stromal cells significantly decreased the decidualization markers PRL and IGFBP1. The attenuation of stromal cell decidualization via CST3 suggests a role for uterine gland-derived proteins in controlling the extent of decidualization. These findings provide evidence that uterine gland-derived factors directly impact stromal cell decidualization, which has strong implications for better understanding pregnancy establishment and female fertility in humans.

2023-10-11 | PXD034357 | Pride

Arid1a is essential for endometrial gland development

Project description:Arid1a has a critical role for modulating endometrial gland develop that is required for normal uterine function and fertility after maturity. We used microarrays to detail the mechanism underlying Arid1a loss during postnatal development.

2019-11-06 | GSE137166 | GEO

Endometrial gland impacts on stromal cell decidualization

Project description:Endometrial gland impacts on stromal cell decidualization

| PRJNA843696 | ENA

Arid1a is essential for endometrial gland development

Project description:Arid1a is essential for endometrial gland development

| PRJNA564689 | ENA

Term placenta transcriptomes

Project description:Term placenta transcriptomes

| PRJNA345631 | ENA

Endometrial gland impacts on stromal cell decidualization

2022-06-06 | GSE205084 | GEO

Human endometrial organoids

Project description:Human endometrial organoids

| PRJNA528264 | ENA

Human endometrial organoids

Project description:Human endometrial organoid cultures were established from the decidual samples. We analyzed the global expression profiles of the endometrial organoids. Next, we determined the global expression patterns upon estrogen treatment and compared them to untreated controls.

2021-01-27 | GSE128605 | GEO

Term placenta syncytiotrophoblast transcriptome

Project description:Placenta is an epitome of cell signalling, including the signalling between two semi-allogenic individuals, mother and fetus. We have studied the putative crosstalk by analyzing the expression of corresponding ligands and receptors on maternal fetal interface. This transcriptome represents one of the important cellular sources, namely the multinucleated fetal layer that is directly bathed in the maternal blood. It was collected by microdissection, as it is too large to be included in the single cell preparation. In combination with other compartments, whose transcriptomes are provided along with this one, we think this study provides a rich resource of gene expression profiles of term placenta.

2017-01-31 | GSE87725 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data