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A high-resolution temporal atlas of the SARS-CoV-2 translatome and transcriptome

ABSTRACT: A high-resolution temporal atlas of the SARS-CoV-2 translatome and transcriptome

PROVIDER: PRJNA661467 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR12588852.fastq.gz	Fastqsanger.gz
	SRR12588853.fastq.gz	Fastqsanger.gz
	SRR12588854.fastq.gz	Fastqsanger.gz
	SRR12588855.fastq.gz	Fastqsanger.gz
	SRR12588856.fastq.gz	Fastqsanger.gz

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A high-resolution temporal atlas of the SARS-CoV-2 translatome and transcriptome

Project description:COVID-19 is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which infected >200 million people resulting in >4 million deaths. However, temporal landscape of the SARS-CoV-2 translatome and its impact on the human genome remain unexplored. Here, we report a high-resolution atlas of the translatome and transcriptome of SARS-CoV-2 for various time points after infecting human cells. Intriguingly, substantial amount of SARS-CoV-2 translation initiates at a novel translation initiation site (TIS) located in the leader sequence, termed TIS-L. Since TIS-L is included in all the genomic and subgenomic RNAs, the SARS-CoV-2 translatome may be regulated by a sophisticated interplay between TIS-L and downstream TISs. TIS-L functions as a strong translation enhancer for ORF S, and as translation suppressors for most of the other ORFs. Our global temporal atlas provides compelling insight into unique regulation of the SARS-CoV-2 translatome and helps comprehensively evaluate its impact on the human genome.

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