Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Impact of Zika Virus Infection on Human Neural Stem Cell MicroRNA Signatures [miRNA-Seq]

ABSTRACT: Impact of Zika Virus Infection on Human Neural Stem Cell MicroRNA Signatures [miRNA-Seq]

PROVIDER: PRJNA661578 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR12595000.fastq.gz	Fastqsanger.gz
	SRR12595001.fastq.gz	Fastqsanger.gz
	SRR12595002.fastq.gz	Fastqsanger.gz
	SRR12595003.fastq.gz	Fastqsanger.gz
	SRR12595004.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 54

Similar Datasets

Impact of Zika Virus Infection on Human Neural Stem Cell MicroRNA Signatures

Project description:Impact of Zika Virus Infection on Human Neural Stem Cell MicroRNA Signatures

| PRJNA661574 | ENA

Impact of Zika Virus Infection on Human Neural Stem Cell MicroRNA Signatures [array]

Project description:Impact of Zika Virus Infection on Human Neural Stem Cell MicroRNA Signatures [array]

| PRJNA661577 | ENA

Impact of Zika Virus Infection on Human Neural Stem Cell MicroRNA Signatures [miRNA-Seq]

Project description:We used next generation sequencing to analyze the effects of Zika virus (ZIKV) strains Uganda and French Polynesia on intracellular and extracellular vesicle (EV) derived miRNA profiles of induced pluripotent stem cell-derived human neural stem cells (long-term self-renewing neuroepithelial-like stem (lt-NES®) cells) - particularly to identify dysregulated miRNAs which are associated with the microcephaly phenotype.

2020-10-31 | GSE157528 | GEO

Impact of Zika Virus Infection on Human Neural Stem Cell MicroRNA Signatures [array]

Project description:We used whole genome expression profiling to analyze the effects of Zika virus (ZIKV) strains Uganda and French Polynesia on the mRNA transcriptome of induced pluripotent stem cell-derived human neural stem cells (long-term self-renewing neuroepithelial-like stem (lt-NES®) cells) - particularly to identify differentially expressed genes which are associated with microcephaly phenotype.

2020-10-31 | GSE157530 | GEO

miRNA analysis of Zika infected neural stem cells

Project description:small RNA-seq was utilized to characterize the transcriptome of human neural stem cells infected with Zika virus strains MR766 and Paraiba at MOI 1. Coding and noncoding genes were analyzed to determine transcriptional changes 3 days post-infection.

2019-06-18 | GSE113639 | GEO

Zika infected neural stem cells

Project description:Zika infected neural stem cells

| PRJNA453491 | ENA

miRNA analysis of Zika infected neural stem cells

Project description:miRNA analysis of Zika infected neural stem cells

| PRJNA453492 | ENA

Differential responses of human fetal brain neural stem cells to Zika virus infection

Project description:Purpose: The goal of this study is to investigate the effect of Zika virus infection on neural stem cells Methods: RNA-Seq transcriptome analysis of neural stem cells infected with Zika virus compared to mock infected

2017-02-17 | GSE93385 | GEO

Molecular Signatures Associated with ZIKV Exposure in Human Cortical Neural Progenitors and Astrocytes

Project description:Zika virus (ZIKV) infection causes microcephaly and has been linked to other brain abnormalities. How ZIKV impairs brain development and function remains elusive. Here we systematically profiled transcriptomes of human neural progenitor cells (hNPCs) and astrocytes exposed to Asian ZIKVC, African ZIKVM, and Dengue virus (DENV). DENV causes distinct gene expression changes; and ZIKV has a broader impact on the expression of gene involved in DNA replication and repair. While overall expression profiles are similar, ZIKVC, but not ZIKVM, induces upregulation of viral response genes. Upon ZIKV infection, astrocytes exhibit more prominent transcriptome changes than hNPCs, particularly enriching genes related to inflammatory response and cytokine production pathways. Our analyses reveal cell-type- and strain-specific molecular signatures associated with ZIKV infection, and identify astrocytes as a major direct target of ZIKV. Further investigation of ZIKV-host interactions based our transcriptomic datasets may help to illuminate neural virulence determinants of ZIKV in patients. Gene Expression Analyses of the cells infected with different flaviviruses

2016-08-23 | E-GEOD-80434 | biostudies-arrayexpress

Impact of Zika Virus Infection on Human Neural Stem Cell MicroRNA Signatures.

Project description:Zika virus (ZIKV) is a mosquito-borne virus, which can cause brain abnormalities in newborns, including microcephaly. MicroRNAs (miRNAs) are small non-coding RNAs, which post- transcriptionally regulate gene expression. They are involved in various processes including neurological development and host responses to viral infection, but their potential role in ZIKV pathogenesis remains poorly understood. MiRNAs can be incorporated into extracellular vesicles (EVs) and mediate cell-to-cell communication. While it is well known that in viral infections EVs carrying miRNAs can play a crucial role in disease pathogenesis, ZIKV effects on EV-delivered miRNAs and their contribution to ZIKV pathogenesis have not been elucidated. In the present study, we profiled intracellular and EV-derived miRNAs by next generation sequencing and analyzed the host mRNA transcriptome of neural stem cells during infection with ZIKV Uganda and French Polynesia strains. We identified numerous miRNAs, including miR-4792, which were dysregulated at the intracellular level and had altered levels in EVs during ZIKV infection. Integrated analyses of differentially expressed genes and miRNAs showed that ZIKV infection had an impact on processes associated with neurodevelopment and oxidative stress. Our results provide insights into the roles of intracellular and EV-associated host miRNAs in ZIKV pathogenesis.

| S-EPMC7693339 | biostudies-literature

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data