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Muscle fibrosis in chronic kidney disease

ABSTRACT: Muscle fibrosis in chronic kidney disease

PROVIDER: PRJNA662524 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR12616238_1.fastq.gz	Fastqsanger.gz
	SRR12616238_2.fastq.gz	Fastqsanger.gz
	SRR12616239_1.fastq.gz	Fastqsanger.gz
	SRR12616239_2.fastq.gz	Fastqsanger.gz
	SRR12616240_1.fastq.gz	Fastqsanger.gz

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Muscle fibrosis in chronic kidney disease

Project description:Patients with chronic kidney disease (CKD) are at markedly increased risk of disability, hospitalization, and death. Impaired physical function, which is common in CKD, is a major risk factor for these poor outcomes. CKD patients perform substantially below age-predicted norms on a variety of clinically relevant physical performance tests. Altered muscle physiology is an important cause of these functional deficits. We recently described skeletal muscle fibrosis in the vastus lateralis muscle of patients with severely impaired kidney function. Greater severity of fibrosis was associated with lower leg extension strength and reduced endurance capacity, suggesting that muscle fibrosis in CKD patients is functionally significant. An important unanswered question is whether muscle fibrosis in CKD is a slowly progressive process beginning with early loss of kidney function, or a complication observed only with severe disease. Here, we examined the associations of estimated glomerular filtration rate (a measure of kidney function) with measures of fibrosis across a broad range of kidney function, and tested the effect of receiving treatment with dialysis. We also integrated muscle transcriptomic analyses to provide further insight into this novel aspect of muscle pathology in CKD.

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