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RNA Sequencing Analysis of Wild Type and Myrf +/− mice Retina

ABSTRACT: RNA Sequencing Analysis of Wild Type and Myrf +/− mice Retina

PROVIDER: PRJNA662876 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR12623327_1.fastq.gz	Fastqsanger.gz
	SRR12623327_2.fastq.gz	Fastqsanger.gz
	SRR12623328_1.fastq.gz	Fastqsanger.gz
	SRR12623328_2.fastq.gz	Fastqsanger.gz
	SRR12623329_1.fastq.gz	Fastqsanger.gz

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RNA Sequencing Analysis of Wild Type and Myrf +/− mice Retina

Project description:We have created a Myrf knockdown (Myrf +/−) mutant mouse strain and investigated the molecular phenotype of reduced MYRF expression in the retina using RNA-sequencing. As an initial finding, photoreceptor defects with impaired functions of spatial vision and retinal electrophysiology were found in Myrf +/− mice, indicating an important role of MYRF in retinal development.It was revealed through RNA-seq that the expression of phototransduction and estrogen signaling pathways reduced in Myrf +/− mice. Thus, alterations of phototransduction and estrogen signaling pathways seem to play important roles in connecting Myrf deficiency with retinal photoreceptor defects.

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Project description:Our research revealed that the transmembrane transcription factors MYRF-1 and MYRF-2 are crucial for activating the microRNA lin-4 at the end of the first larval stage in C. elegans. To determine whether MYRF regulates other microRNA genes during this period, we conducted a microRNA sequencing analysis to compare microRNA expression in late L1 larvae of wild type and myrf-1(ju1121) mutants. The myrf-1(ju1121) mutation causes a loss of function in both MYRF-1 and MYRF-2. Our analysis identified a subset of microRNAs that were differentially expressed between the wild type and the myrf-1(ju1121) mutants.

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MicroRNA profiling of mouse wild type (C57 and 129) retina and retina from a mouse model of retinitis pigmentoas (Pro347Ser)

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Gene expression in retina and LGN of wild type and Chrnb2-/- mice

Project description:Mice lacking the beta 2 subunit (Chrnb2) of the neuronal nicotinic acetylcholine receptor display altered retinal waves and disorganized projections of the retinal ganglion cells to the lateral geniculate nucleus (LGN). mRNA populations from retinas and LGN from Chrnb2-/-and wild type (C57BL/6J) mice were compared at 4 days postnatal, when RGC segregation to the LGN begins in WT mice. Retinal mRNAs were also compared at adulthood. Using microarray hybridization, we identified transcripts which are differentially expressed between Chrnb2-/- and wild type animals in these two tissues at these two ages. mRNA was isolated from retina and LGN of three male littermates each of WT and Chrnb2-/- mice at P4. mRNA from retinas of two adult male littermates of each type was also examined.

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