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CircRNA microarray profile analysis in esophageal squamous cell carcinoma(ESCC) and adjacent normal tissues

ABSTRACT: circRNA microarray profile analysis in esophageal squamous cell carcinoma(ESCC) and adjacent normal tissues

PROVIDER: PRJNA662878 | ENA |

REPOSITORIES: ENA

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circRNA microarray profile analysis in esophageal squamous cell carcinoma(ESCC) and adjacent normal tissues

Project description:The circRNA expression profile related to ESCC in high-incidence areas of China was successfully constructed, and differentially expressed circRNAs were screened out and their functions were predicted.The circRNA expression in ESCC tissues was significantly different from that in adjacent normal tissues.GO and Pathway analysis showed that differentially expressed circRNAs were mainly involved in biological functions such as cellular process, metabolic process, biological regulation, binding and catalytic activity, and involved in multiple regulatory pathways including extracellular matrix receptor interaction, adhesion spot, protein digestion and absorption.Then their circRNA-miRNA network was constructed to better understand the related mechanism of circRNAs and provide ideas for exploring the biology functions of circRNAs in ESCC, revealing that the differentially expressed circRNAs were closely related to ESCC.

2023-09-10 | GSE157803 | GEO

Expression data from esophageal squamous cell carcinoma (ESCC)

Project description:We used microarrays to determine global gene expression in primary tumor tissues (ESCC) and matched normal tissues (adjacent normal esophageal mucosa) Paired primary ESCC tumor and normal tissues were compared (n=5).

2009-09-01 | E-GEOD-17351 | biostudies-arrayexpress

microRNA microarray profile analysis in esophageal squamous cell carcinoma(ESCC) and adjacent normal tissues

Project description:The miRNA expression profile related to ESCC in high-incidence areas of China was successfully constructed, and differentially expressed miRNAs were screened out and their functions were predicted.The miRNA expression in ESCC tissues was significantly different from that in adjacent normal tissues.GO and Pathway analysis showed that differentially expressed miRNAs were mainly involved in biological functions such as cellular process, metabolic process, biological regulation, binding and catalytic activity, and involved in multiple regulatory pathways including extracellular matrix receptor interaction, adhesion spot, protein digestion and absorption.Then their circRNA-miRNA network was constructed to better understand the related mechanism of miRNAs and provide ideas for exploring the biology functions of miRNAs in ESCC, revealing that the differentially expressed miRNAs were closely related to ESCC.

2023-09-10 | GSE157805 | GEO

Expression data from esophageal squamous cell carcinoma (ESCC)

Project description:We used microarrays to determine global gene expression in primary tumor tissues (ESCC) and matched normal tissues (adjacent normal esophageal mucosa)

2009-09-01 | GSE17351 | GEO

lncRNAs and mRNAs expression data in esophageal squamous cell carcinoma(ESCC) and adjacent normal tissues

Project description:The differential expression profile of lncRNAs and mRNAs in esophageal squamous cell carcinoma in high-incidence areas of China was constructed and co-expression correlation analysis was performed. The expression profile of lncRNAs in ESCC tissues was significantly different from that in adjacent normal tissues. Co-expression analysis revealed that lncRNA may be involved in the occurrence and development of esophageal cancer, thus providing a new basis for the diagnosis and treatment of esophageal cancer.

2023-09-10 | GSE157804 | GEO

Analysis of gene expression in esophageal squamous cell carcinoma (ESCC)

Project description:To characterize gene expression in esophageal squamous cell carcinoma, we examined gene expression in tumor and matched normal adjacent tissue from 17 ESCC patients from a high-risk region of China.

2011-03-15 | GSE20347 | GEO

Analysis in esophageal squamous cell carcinoma(ESCC) and adjacent normal tissues

Project description:Analysis in esophageal squamous cell carcinoma(ESCC) and adjacent normal tissues

| PRJNA662877 | ENA

Expression data from human Esophageal squamous cell carcinoma (ESCC)

Project description:Downregulation is a common feature of tumor suppressor gene (TSG), which can be caused by allele deletion, promoter hypermethylation, histone deacetylation and posttranscriptional silencing by microRNA. Therefore, comparison of expression profiles by cDNA microarray between tumor and non-tumor tissues and characterization of downregulated genes in tumor specimens is a useful strategy to identify TSGs. To identify deregulated genes during ESCC development, Affemetrix cDNA microarray was applied to compare differentially expressed genes between 4 pairs of ESCC tumors and corresponding adjacent non-tumor tissues (#301, #327, #351 and #363), and one pair of esophageal dysplasia tissue and adjacent normal tissue (#314).

2017-07-15 | GSE100942 | GEO

microRNA microarray profile analysis in esophageal squamous cell carcinoma(ESCC) and adjacent normal tissues

Project description:microRNA microarray profile analysis in esophageal squamous cell carcinoma(ESCC) and adjacent normal tissues

| PRJNA662880 | ENA

DNA methylation analysis in esophageal squamous cell carcinoma(ESCC) and adjacent normal tissues

Project description:DNA methylation related to ESCC in high-incidence areas of China was successfully constructed, and differentially DNA methylation were screened out and their functions were predicted.The DNA methylation in ESCC tissues was significantly different from that in adjacent normal tissues.

2023-09-10 | GSE157807 | GEO

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