Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Detecting lncRNA fusion events in breast cancer cells

ABSTRACT: Detecting lncRNA fusion events in breast cancer cells

PROVIDER: PRJNA663591 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR12644174_1.fastq.gz	Fastqsanger.gz
	SRR12644174_2.fastq.gz	Fastqsanger.gz

Items per page:

1 - 2 of 2

Similar Datasets

Detecting lncRNA fusion events in breast cancer cells

Project description:We deep-sequenced the breast cancer cell line SKBR3 to detect fusion events involving lncRNAs for experimental validation

2020-12-22 | GSE157986 | GEO

Frequent miRNA-convergent fusion gene events in breast cancer

Project description:Studies of fusion genes have mainly focused on the formation of fusions that result in the production of hybrid proteins or, alternatively, on promoter-switching events that put a gene under the control of aberrant signals. However, gene fusions may also disrupt the transcriptional control of genes that are encoded in introns downstream of the breakpoint. By ignoring structural constraints of the transcribed fusions, we highlight the importance of a largely unexplored function of fusion genes. Using breast cancer as an example, we show that miRNA host genes are specifically enriched in fusion genes and that many different, low-frequency, 5' partners may deregulate the same miRNA irrespective of the coding potential of the fusion transcript. These results indicate that the concept of recurrence, defined by the rate of functionally important aberrations, needs to be revised to encompass convergent fusions that affect a miRNA independently of transcript structure and protein-coding potential.

2017-10-31 | GSE100769 | GEO

Detecting intragenic trans-splicing events with hybrid transcriptome sequencing in cancer cells

Project description:Detecting intragenic trans-splicing events with hybrid transcriptome sequencing in cancer cells

| PRJNA976465 | ENA

Mitochondrial fusion limits breast cancer metastasis

Project description:Mitochondrial fusion limits breast cancer metastasis

| PRJNA1027379 | ENA

Circulating microRNA Biomarker for Detecting Breast Cancer in High-Risk Benign Breast Tumors

Project description:Circulating microRNA Biomarker for Detecting Breast Cancer in High-Risk Benign Breast Tumors

| PRJNA934049 | ENA

Mitochondrial fusion limits breast cancer metastasis

Project description:Mitochondrial metabolism plays a central role in promoting cancer growth and metastatic progression. The transition between a hyperfused and fragmented mitochondrial network is termed mitochondrial dynamics and is important for many mitochondria-associated functions; however, little is known regarding how this process influences metastasis. Here, we show that breast cancer cells with low metastatic potential exhibit a more fused mitochondrial network compared to highly metastatic breast cancer cells. To examine whether a fused mitochondrial network could impair metastasis, we inhibited mitochondrial fission in metastatic breast cancer cells by individual genetic deletion of three key regulators of mitochondrial fission (Drp1, Fis1 and Mff) or pharmacological intervention using leflunomide, an anti-rheumatic drug. These cells displayed a fused mitochondrial network and limited survival under anoikis conditions, consistent with mitochondrial fusion limiting metastasis. Transcriptomics and metabolomics analyses revealed that mitochondrial fusion causes significant alterations in metabolic pathways and processes related to cell adhesion. Functional bioenergetics assays demonstrated that mitochondrial fusion limited the mitochondrial capacity of cancer cells. Mitochondrial fusion in breast cancer cells had no significant effect on primary tumor growth but almost completely ablated lung metastasis in vivo. Furthermore, the transcriptomics signature associated with enhanced mitochondrial fusion correlated with improved survival in patients with breast cancer. Overall, our findings highlight mitochondrial fusion as a therapeutic opportunity for breast cancer.

2024-09-25 | GSE245216 | GEO

LncRNA MAGI2-AS3-encoded polypeptide restrains the proliferation and migration of breast cancer cells

Project description:This study was conducted by using Flag tag to IP proteins expressed with fusion small peptides encoding LncRNA MAGI2-AS3 and identified by high resolution mass spectrometry.

2023-03-06 | PXD040607 |

Fusion discovery in breast cancer cell line

Project description:SnowShoes-FTD, a fusion transcript discovery tool, was used to identify fusions in breast cancer cell lines using the RNA-Seq data

2013-11-22 | GSE52643 | GEO

Fusion discovery in breast cancer cell line

Project description:SnowShoes-FTD, a fusion transcript discovery tool, was used to identify fusions in breast cancer cell lines using the RNA-Seq data Total RNA extracted from cell lines. The total RNA was used for construction of RNA-Seq library for RNA-Sequencing.

2013-11-22 | E-GEOD-52643 | biostudies-arrayexpress

Identification of novel gene amplification events in breast cancer

Project description:To identify novel gene amplification events that may contribute to breast cancer progression, we examined copy number variation in 161 primary breast cancer samples using the Affymetrix 250K_Nsp and 250K_Sty microarrays or the Affymetrix SNP5.0 microarray.

2009-09-16 | GSE16619 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data