Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

In severe COVID-19, SARS-CoV-2 induces a chronic, TGF-β-dominated adaptive immune response

ABSTRACT: In severe COVID-19, SARS-CoV-2 induces a chronic, TGF-β-dominated adaptive immune response

PROVIDER: PRJNA663799 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

In severe COVID-19, SARS-CoV-2 induces a chronic, TGF-β-dominated adaptive immune response (Bronchoalveolar lavage)

Project description:In severe COVID-19, SARS-CoV-2 induces a chronic, TGF-β-dominated adaptive immune response (Bronchoalveolar lavage)

| PRJNA663840 | ENA

In severe COVID-19, SARS-CoV-2 induces a chronic, TGF-β-dominated adaptive immune response (Measles-reactive T cells)

Project description:In severe COVID-19, SARS-CoV-2 induces a chronic, TGF-β-dominated adaptive immune response (Measles-reactive T cells)

| PRJNA663839 | ENA

In severe COVID-19, SARS-CoV-2 induces a chronic, TGF-β-dominated adaptive immune response (Activated B cells, Set 2)

Project description:In severe COVID-19, SARS-CoV-2 induces a chronic, TGF-β-dominated adaptive immune response (Activated B cells, Set 2)

| PRJNA663838 | ENA

In severe COVID-19, SARS-CoV-2 induces a chronic, TGF-β-dominated adaptive immune response (Activated B cells, set 1)

Project description:In severe COVID-19, SARS-CoV-2 induces a chronic, TGF-β-dominated adaptive immune response (Activated B cells, set 1)

| PRJNA663837 | ENA

In severe COVID-19, SARS-CoV-2 induces a chronic, TGF-β-dominated adaptive immune response (Bronchoalveolar lavage)

Project description:Single cell transcriptome, TCR and BCR sequencing of FACS-sorted CD45+ cells of the bronchoalveolar lavages of COVID-19 ICU patients

2021-02-09 | GSE158037 | GEO

In severe COVID-19, SARS-CoV-2 induces a chronic, TGF-β-dominated adaptive immune response (Activated B cells, Set 2)

Project description:Single cell transcriptome and BCR sequencing of FACS-sorted activated B cells of the peripheral blood of COVID-19 ICU patients and healthy controls

2021-02-09 | GSE158034 | GEO

In severe COVID-19, SARS-CoV-2 induces a chronic, TGF-β-dominated adaptive immune response (Activated B cells, set 1)

Project description:Single cell transcriptome and BCR sequencing of FACS-sorted activated B cells of the peripheral blood of COVID-19 ICU patients and healthy controls

2021-02-09 | GSE158030 | GEO

A single-cell atlas of lymphocyte adaptive immune repertoires and transcriptomes reveals age-related differences in convalescent COVID-19 patients

Project description:We utilize single-cell sequencing (scSeq) of lymphocyte immune repertoires and transcriptomes to quantitatively profile the adaptive immune response in COVID-19 patients of varying age. Our scSeq analysis defines the adaptive immune repertoire and transcriptome in convalescent COVID-19 patients and shows important age-related differences implicated in immunity against SARS-CoV-2.

2021-03-20 | E-MTAB-10169 | biostudies-arrayexpress

Temporal dynamics of the host molecular responses underlying severe COVID-19 progression and disease resolution

Project description:Manuscript describes the daily dynamics of transcriptional responses in whole blood, from acute to convalescent phase, in severe and non-severe COVID-19 patients.

2020-12-31 | E-MTAB-9721 | biostudies-arrayexpress

Immunophenotyping of COVID-19 and Influenza Underscores the Association of Type I IFN Response in Severe COVID-19

Project description:Although most SARS-CoV-2-infected individuals experience mild COVID-19, some patients suffer from severe COVID-19, which is accompanied by acute respiratory distress syndrome and systemic inflammation. To identify factors driving severe progression of COVID-19, we performed single-cell RNA-seq using peripheral blood mononuclear cells (PBMCs) obtained from healthy donors, patients with mild or severe COVID-19, and patients with severe influenza. Patients with COVID-19 exhibited hyper-inflammatory signatures across all types of cells among PBMCs, particularly upregulation of the TNF/IL-1beta-driven inflammatory response as compared to severe influenza. In classical monocytes from patients with severe COVID-19, type I IFN response co-existed with the TNF/IL-1beta-driven inflammation, and this was not seen in patients with milder COVID-19 infection. Based on this, we propose that the type I IFN response exacerbates inflammation in patients with severe COVID-19 infection.

2020-07-06 | GSE149689 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data