Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Comparison of germ free and colonized mouse livers at baseline and 3 hours post partial hepatectomy

ABSTRACT: Comparison of germ free and colonized mouse livers at baseline and 3 hours post partial hepatectomy

PROVIDER: PRJNA664201 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR12664200_1.fastq.gz	Fastqsanger.gz
	SRR12664200_2.fastq.gz	Fastqsanger.gz
	SRR12664201_1.fastq.gz	Fastqsanger.gz
	SRR12664201_2.fastq.gz	Fastqsanger.gz
	SRR12664190_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 24

Similar Datasets

Comparison of transcriptional changes in regenerating mice livers at baseline and 3-12 hours post 70% partial hepatectomy

Project description:To refine the timeframe of liver regeneration initiation and investigate the temporal characteristics of metabolic reprogramming in the preparatory stage, we here established partial hepatectomy model and performed gene expression profiling analysis using data obtained from RNA-seq of regenerating livers at different time points.

2025-03-01 | GSE255995 | GEO

Comparison of germ free and colonized mouse livers at baseline and 3 hours post partial hepatectomy

Project description:The microbiota is known to exert substantial effects on shaping an organism's immune system and immune composition of organs. Here we questioned the effect of the microbiota on the transcriptional signature of mouse liver tissue at baseline and during regeneration.

2023-04-05 | GSE158174 | GEO

Comparison of transcriptional changes in regenerating mice livers at baseline and 24-48 hours post 70% partial hepatectomy with or without etomoxir treatment

Project description:To investigate liver transcriptomes in the proliferative stage of early liver regeneration, we here established 70% partial hepatectomy model and performed gene expression profiling analysis using data obtained from RNA-seq of regenerating livers at different time points.

2025-03-01 | GSE256002 | GEO

Comparison of transcriptional changes in regenerating mice livers at baseline and 3-12 hours post 70% partial hepatectomy

Project description:Comparison of transcriptional changes in regenerating mice livers at baseline and 3-12 hours post 70% partial hepatectomy

| PRJNA1077368 | ENA

Wild type (WT), partial hepatectomy, and lncHand2 KO chip

Project description:To identify differential genes after partial hepatectomy, we performed gene chip analysis of livers from wild type (WT) mouse and PHx 36h mouse livers To find differential genes regulated by lncHand2, we performed gene chip analysis from WT and lncHand2 deficiency livers.

2017-04-29 | GSE98357 | GEO

Gene expression profiling by bulk RNAseq from the livers of wild-type mice and those with loss-of-function mutations in URI 48 hours after partial hepatectomy

Project description:We used bulk RNA sequencing to examine the differentially expressed genes in the livers of URI loss-of-function mutant (specific deletion of URI in hepatocytes using serum albumin-creERT2 line) and wild-type littermate control mice 48 hours after partial hepatectomy (48H).

2025-02-07 | GSE281923 | GEO

Genome-wide expression profiling of Uhrf1hepKO mouse livers at baseline and following PHx

Project description:This study was carried out to investigate the mechanism behind the enhanced liver regenerative response observed in Uhrf1hepKO mice. Livers was collected at baseline and at 24hrs, 30hrs, 40hrs, 48hrs, 96hrs, 7days and 4 weeks following 2/3 partial hepatectomy surgery (PHx). These timepoints correspond to key cell cycle events that occur following PHx as established in literature.

2019-05-31 | GSE125007 | GEO

Comparison of transcriptional changes in regenerating mice livers at baseline and 24-48 hours post 70% partial hepatectomy with or without etomoxir treatment

Project description:Comparison of transcriptional changes in regenerating mice livers at baseline and 24-48 hours post 70% partial hepatectomy with or without etomoxir treatment

| PRJNA1077372 | ENA

Effect of conditional deletion of S6 ribosomal protein following partial hepatectomy

Project description:Deletion of the RPS6 gene in mouse liver results in the inhibition of 40S ribosome biogenesis and the failure of hepatocytes to enter S-phase following partial hepatectomy. This microarray experiment was designed to assess the effects of RPS6 deletion on the expression of genes involved in liver regeneration following partial hepatectomy. Keywords: time course, liver RNA was isolated from mouse livers at different time-points following partial hepatectomy. Conditional deletion of the RPS6 gene was perfomed by injecting polyinosinic-polycytidylic acid in mice harbouring a floxed version of the RPS6 gene and a cre recombinase under the regulation of an interferon responsive promoter (MX-CRE). The mice used a control have also a floxed version of the RPS6 gene but lack the cre recombinaste transgene.

2009-05-01 | E-GEOD-13864 | biostudies-arrayexpress

Transcription profiling of mouse liver regeneration after partial hepatectomy

Project description:The goal of this study is to obtain an expression profile of regenerating mouse livers. We used microarray analysis to study the gene groups coordinately expressed temporally during mouse a liver regeneration. One of the syn-expression groups that showed a sharp rise in gene expression immediately after hepatectomy contains a set pancreatic exocrine genes. The syn-expression profile of pancreatic genes and the pancreatic-specific transcription factors Ptf1a and Ipf1 was confirmed using real-time PCR. Electron microscopic examination showed the presence of morphological features reminiscent of pancreatic acinar cells with the presence of characteristic zymogen granules and ER organization. These results indicate that there is a transient liver-to-pancreas transdifferentiation event at the beginning of liver regeneration. A strong coordinated up-regulation of pancreatic genes was found to accompany the injury response in the pancreas, suggesting a compensatory mechanism for pancreatic functions. There seems to be a relationship between the induction of pancreatic genes and acute phase response at the beginning of liver regeneration. Experiment Overall Design: Total RNA was extracted from livers of mice recovered at Experiment Overall Design: various hours after partial hepatectomy (PHx 4h, 8h, 12h, 36h, Experiment Overall Design: 48h, 72h). We grouped livers of four to six mice together for Experiment Overall Design: RNA extraction. Genes showed differentially up- or downregulated Experiment Overall Design: by two-fold with respect to the normal mouse livers Experiment Overall Design: were identified using GeneSpring software version 7.2 (Silicon Experiment Overall Design: Genetics, Agilent Technologies).

2008-06-13 | E-GEOD-4528 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data