Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Targeting Set7 in an experimental model of diabetic nephropathy

ABSTRACT: Targeting Set7 in an experimental model of diabetic nephropathy

PROVIDER: PRJNA666001 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR12721207_1.fastq.gz	Fastqsanger.gz
	SRR12721207_2.fastq.gz	Fastqsanger.gz
	SRR12721208_1.fastq.gz	Fastqsanger.gz
	SRR12721208_2.fastq.gz	Fastqsanger.gz
	SRR12721209_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 56

Similar Datasets

Targeting Set7 in an experimental model of diabetic nephropathy

Project description:Set7 knockout (Set7KO) improved glomerular structure and albuminuria in a mouse model of diabetes. Analysis of mouse single-cell RNA-sequencing data showed dynamic transcriptional changes in diabetic renal cells. Set7KO controls phenotype switching of GEN cell populations through transcriptional regulation of the insulin growth factor binding protein 5 (IGFBP5). Chromatin immunoprecipitation assays confirmed that the expression of the IGFBP5 gene was associated with mono- and dimethylation of histone H3 lysine 4 (H3K4me1/2). This generalizability was investigated in human renal and circulating hyperglycemic cells exposed to TGFb1. We showed that the highly selective Set7 inhibitor PFI-2 attenuated indices associated with renal cell damage and mesenchymal transition, specifically (1) reactive oxygen species production, (2) IGFBP5 gene regulation, and (3) expression of mesenchymal markers. Furthermore, renal benefit observed in Set7KO diabetic mice closely corresponds in human glomerular endothelial cells with PFI-2 inhibition or Set7 shRNA silencing.

2024-04-17 | GSE158626 | GEO

Diabetic nephropathy

Project description:Gene expression profiling in glomeruli from human kidneys with diabetic nephropathy Keywords = Diabetes Keywords = kidney Keywords = glomeruli Keywords: other

2004-04-01 | GSE1009 | GEO

Human PBMCs: Healthy vs Diabetic nephropathy vs ESRD

Project description:Transcriptional profiling of human PBMCs comparing healthy controls, patients with diabetic nephropathy and patients with ESRD. PBMCs were analyzed as they mediate inflammatory injury. Goal was to determine effects of increasing severity of diabetic nephropathy on global PBMC gene expression. Microarray analysis of PBMCs taken from patients with varying degrees of diabetic nephropathy.

2020-12-01 | GSE142153 | GEO

diabetic nephropathy streptozotocin db db

Project description:diabetes, mouse models, diabetic nephropathy, streptozotocin db/db Keywords: other

2004-01-20 | GSE710 | GEO

Cellular and Molecular Linkage between Diabetic Nephropathy and Diabetic Retinopathy

Project description:Diabetic nephropathy and diabetic retinopathy are related. We used scRNA-seq and RNA-seq to analyze the cellular linkage between them.

2023-08-15 | GSE204880 | GEO

gut microbiome in diabetic nephropathy

Project description:gut microbiome in diabetic nephropathy

| PRJEB36826 | ENA

LncRNAs expression profiles in renal tissues from patients with diabetic nephropathy

Project description:In order to more accurately and objectively clarify the biological role of lncRNAs in diabetic nephropathy, we detected their expression profiles in renal tissues from patients with diabetic nephropathy.

2022-11-24 | GSE218344 | GEO

Unveiling FOS as a Potential Diagnostic Biomarker and Emetine as a Prospective Therapeutic Agent for Diabetic Nephropathy

Project description:To gain a comprehensive understanding of emetine's impact on high glucose-induced M1 macrophage polarization in the pathogenesis of diabetic nephropathy (DN), we employed transcriptome sequencing. Our study included two experimental groups: the high glucose-induced damage group and the high glucose-induced damage with emetine pretreatment group. Differential gene expression analysis, accompanied by functional enrichment analysis, was conducted to identify crucial pathways and biological processes involved. This investigation provides significant insights into the role of emetine in DN, enhancing our knowledge regarding its underlying mechanisms. Furthermore, this research contributes to a deeper comprehension of the pathogenesis of diabetic nephropathy and offers valuable prospects for the development of potential therapeutic targets and strategies for diabetic nephropathy.

2024-01-02 | GSE239385 | GEO

The Single Cell Transcriptomic Landscape of Early Human Diabetic Nephropathy

Project description:We report the early transcriptional changes in human diabetic nephropathy by single nucleus RNA sequencing

2019-09-10 | GSE131882 | GEO

Gene expression profiling in glomeruli from human kidneys with diabetic nephropathy

Project description:Gene expression profiling in glomeruli from human kidneys with diabetic nephropathy Keywords = Diabetes Keywords = kidney Keywords = glomeruli Keywords: other. This dataset is part of the TransQST collection.

2004-04-01 | E-GEOD-1009 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data