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The Bromodomain Containing 8 (BRD8) Transcriptional Network in Human Lung Epithelial Cells [RNA-Seq]

ABSTRACT: The Bromodomain Containing 8 (BRD8) Transcriptional Network in Human Lung Epithelial Cells [RNA-Seq]

PROVIDER: PRJNA666177 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR12732975.fastq.gz	Fastqsanger.gz
	SRR12732976.fastq.gz	Fastqsanger.gz
	SRR12732977.fastq.gz	Fastqsanger.gz
	SRR12732978.fastq.gz	Fastqsanger.gz
	SRR12732979.fastq.gz	Fastqsanger.gz

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The Bromodomain Containing 8 (BRD8) Transcriptional Network in Human Lung Epithelial Cells [ChIP-seq]

Project description:Mechanisms regulating gene expression in the airway epithelium underlie its response to the environment. A network of transcription factors (TFs) and architectural proteins, modulate chromatin accessibility and recruit activating or repressive signals. Bromodomain-containing proteins function as TFs or by engaging methyltransferase or acetyltransferase activity to induce chromatin modifications. Here we investigate the role of Bromodomain Containing 8 (BRD8) in coordinating lung epithelial function. Sites of BRD8 occupancy genome-wide were mapped in human lung epithelial cell lines (Calu-3 and 16HBE14o-). CCCTC-Binding Factor (CTCF) was identified as a predicted co-factor of BRD8, based upon motif over-representation under BRD8 ChIP-seq peaks. Following siRNA-mediated depletion of BRD8, differentially expressed genes with peaks of BRD8 occupancy within 20 kb were subject to gene ontology process enrichment analysis. BRD8 targets are enriched for genes involved in the innate immune response and depletion of BRD8 increased the secretion of the antimicrobial peptide beta-defensin 1 and multiple chemokines.

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The Bromodomain Containing 8 (BRD8) Transcriptional Network in Human Lung Epithelial Cells [RNA-Seq]

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The Bromodomain Containing 8 (BRD8) Transcriptional Network in Human Lung Epithelial Cells

Project description:The Bromodomain Containing 8 (BRD8) Transcriptional Network in Human Lung Epithelial Cells

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The Bromodomain Containing 8 (BRD8) Transcriptional Network in Human Lung Epithelial Cells [ChIP-seq]

Project description:The Bromodomain Containing 8 (BRD8) Transcriptional Network in Human Lung Epithelial Cells [ChIP-seq]

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The Bromodomain Containing 8 (BRD8) Transcriptional Network in Human Lung Epithelial Cells

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-01-29 | GSE158688 | GEO

Genomic BRD8-binding sites in human colorectal cancer cells

Project description:Although BRD8 has been considered to act as a coactivator of the NuA4/TIP60-histone acetyltransferase complex, the role of BRD8 in colorectal cancer cells remains to be elucidated. We explored genomic BRD8-binding sites in human colorectal cancer cells.

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BRD8 maintains glioblastoma by epigenetic reprogramming of the P53 network

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Bromodomain-containing Protein 4 (BRD4) is Required for the Maintenance of a Mammary Epithelial Phenotype

Project description:Bromodomain-containing Protein 4 (BRD4) is Required for the Maintenance of a Mammary Epithelial Phenotype

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Bromodomain-containing Protein 4 (BRD4) is Required for the Maintenance of a Mammary Epithelial Phenotype [RNA-Seq]

Project description:Bromodomain-containing protein 4 (BRD4) is an important epigenetic reader which promotes gene transcription to modulate cell-specific functions and is under intensive investigation for its potential as an anti-tumor therapeutic target. However, the role of BRD4 in non-transformed cells remains unclear. Here we demonstrate that BRD4 is required for the expression of epithelial-specific genes and suppression of stem cell-like properties by binding to the distal regions of epithelial-related genes. Moreover, BRD4 occupancy correlates with enhancer activity and enhancer RNA (eRNA) transcription of epithelial differentiation-specific genes. Interestingly, we show that BRD4 perturbation regulates the expression of Grainy Head-like transcription factor, GRHL3, whose depletion partially mimics BRD4 inhibition and blocks differentiated phenotype. By binding to the distal regions of GRHL3, BRD4 promotes RNA polymerase-II occupancy and thus affects eRNA transcription. Altogether, these findings provide evidence that BRD4 promotes a differentiated epithelial phenotype in non-transformed mammary cells at least in part through the activation of GRHL3 expression.

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Bromodomain-containing Protein 4 (BRD4) is Required for the Maintenance of a Mammary Epithelial Phenotype [ChIP-Seq]

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