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Amino acids activate mTORC1 to release roe deer embryos from decelerated proliferation during diapause [Luminal epithelium]

ABSTRACT: Amino acids activate mTORC1 to release roe deer embryos from decelerated proliferation during diapause [Luminal epithelium]

PROVIDER: PRJNA666550 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR12746100.fastq.gz	Fastqsanger.gz
	SRR12746101.fastq.gz	Fastqsanger.gz
	SRR12746102.fastq.gz	Fastqsanger.gz
	SRR12746103.fastq.gz	Fastqsanger.gz
	SRR12746104.fastq.gz	Fastqsanger.gz

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Amino acids activate mTORC1 to release roe deer embryos from decelerated proliferation during diapause

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Amino acids activate mTORC1 to release roe deer embryos from decelerated proliferation during diapause [Luminal epithelium]

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Amino acids activate mTORC1 to release roe deer embryos from decelerated proliferation during diapause.

Project description:Embryonic diapause in mammals leads to a reversible developmental arrest. While completely halted in many species, European roe deer (Capreolus capreolus) embryos display a continuous deceleration of proliferation. During a 4-mo period, the cell doubling time is 2 to 3 wk. During this period, the preimplantation blastocyst reaches a diameter of 4 mm, after which it resumes a fast developmental pace to subsequently implant. The mechanisms regulating this notable deceleration and reacceleration upon developmental resumption are unclear. We propose that amino acids of maternal origin drive the embryonic developmental pace. A pronounced change in the abundance of uterine fluid mTORC1-activating amino acids coincided with an increase in embryonic mTORC1 activity prior to the resumption of development. Concurrently, genes related to the glycolytic and phosphate pentose pathway, the TCA cycle, and one carbon metabolism were up-regulated. Furthermore, the uterine luminal epithelial transcriptome indicated increased estradiol-17β signaling, which likely regulates the endometrial secretions adapting to the embryonic needs. While mTORC1 was predicted to be inactive during diapause, the residual embryonic mTORC2 activity may indicate its involvement in maintaining the low yet continuous proliferation rate during diapause. Collectively, we emphasize the role of nutrient signaling in preimplantation embryo development. We propose selective mTORC1 inhibition via uterine catecholestrogens and let-7 as a mechanism regulating slow stem cell cycle progression.

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