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Circular RNA expression analysis of orbital venous malformation [RNA-Seq]

ABSTRACT: Circular RNA expression analysis of orbital venous malformation [RNA-Seq]

PROVIDER: PRJNA666558 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR12746502.fastq.gz	Fastqsanger.gz
	SRR12746503.fastq.gz	Fastqsanger.gz
	SRR12746504.fastq.gz	Fastqsanger.gz
	SRR12746505.fastq.gz	Fastqsanger.gz
	SRR12746506.fastq.gz	Fastqsanger.gz

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Circular RNA expression analysis of orbital venous malformation [RNA-Seq]

Project description:This research aimed to investigate the aberrant expression of circRNA, messenger RNA, and microRNA in orbital venous malformation. A competitive endogenous RNA network was constructed to elucidate their potential roles in orbital venous malformation.

2022-07-06 | GSE158791 | GEO

Circular RNA expression analysis of orbital venous malformation [miRNA-Seq]

2022-07-06 | GSE158793 | GEO

Circular RNA expression analysis of orbital venous malformation

Project description:Circular RNA expression analysis of orbital venous malformation

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Circular RNA expression analysis of orbital venous malformation [miRNA-Seq]

Project description:Circular RNA expression analysis of orbital venous malformation [miRNA-Seq]

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Circular RNA expression analysis of orbital venous malformation

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-07-06 | GSE158798 | GEO

Comprehensive circular RNA expression profiling with associated ceRNA network in orbital venous malformation.

Project description:PurposeOrbital venous malformation (OVM), the most common type of vascular malformation in adults, has a great impact on both visual and cosmetic factors. Circular RNAs (circRNAs) play important roles in various ophthalmological diseases; however, little is known about their function in the pathogenesis of OVM.MethodsWe obtained differentially expressed circRNAs, mRNAs, and miRNAs based on RNA sequencing of four OVM tissues and four normal orbital vascular tissues. The circRNA-mRNA coexpression network and circRNA-miRNA-mRNA and competing endogenous RNA (ceRNA) networks were constructed using miRanda software. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were performed to identify the up- and downregulated mRNAs in the circRNA-miRNA-mRNA ceRNA network.ResultsOverall, we identified 45 upregulated and 144 downregulated circRNAs, as well as 2,175 upregulated and 1,274 downregulated mRNAs and 156 upregulated and 168 downregulated miRNAs in OVM samples compared with normal orbital vascular tissues. The expression changes of mRNAs and circRNAs detected by quantitative real-time PCR (qRT-PCR) were in line with the RNA-seq results. Then, a ceRNA regulatory network was constructed with these differentially expressed circRNAs, mRNAs, and miRNAs. GO functional analysis revealed that most related biological processes involved extracellular matrix organization, positive regulation of actin nucleation, and so on, which were thought to be involved in the evolution of OVM. KEGG pathway analysis of upregulated mRNAs showed that mucin-type O-glycan biosynthesis, glycosaminoglycan degradation, and the PI3K (Gene ID: 5290; OMIM: 613089)-AKT (Gene ID: 207; OMIM: 114500) signaling pathway were all enriched in OVM samples.ConclusionsOur study provides novel insight into the regulatory mechanism of circRNAs, miRNAs, and mRNAs in the pathogenesis of OVM.

| S-EPMC9239899 | biostudies-literature

Expression and Possible Mechanism of circular RNA rno_CIRCpedia_1953 in Deep Venous Thrombosis (circular RNA)

Project description:Expression and Possible Mechanism of circular RNA rno_CIRCpedia_1953 in Deep Venous Thrombosis (circular RNA)

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Expression data: Venous malformation-causative TIE2-mutations mediate an AKT-dependent decrease in PDGFB

Project description:Comparison of transcriptional profiles of human umbilical vein endothelial cells (HUVECs) expressing wild-type vs. VM-causative mutant forms of TIE2/TEK. The effects of the most common Venous Malformation-causative mutations in the endothelial cell tyrosine kinase receptor: R849W and L914F, were tested. 743 genes were differentially expressed across the four groups. The 80 genes distinguishing between L914F and wild-type TIE2-expressing HUVECs were analyzed in greater detail. 3 batches each of: non-transfected, and wild-type TIE2, R849W-TIE2, and L914F-TIE2 overexpressing HUVECs were compared by exon-array profiling.

2013-06-04 | E-GEOD-46684 | biostudies-arrayexpress

Expression data: Venous malformation-causative TIE2-mutations mediate an AKT-dependent decrease in PDGFB

2013-06-04 | GSE46684 | GEO

Expression and Possible Mechanism of circular RNA rno_CIRCpedia_1953 in Deep Venous Thrombosis (RNA)

Project description:Expression and Possible Mechanism of circular RNA rno_CIRCpedia_1953 in Deep Venous Thrombosis (RNA)

| PRJNA623910 | ENA