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RNA-seq for UBR5-regulated genes in tumor associated macrophages

ABSTRACT: RNA-seq for UBR5-regulated genes in tumor associated macrophages

PROVIDER: PRJNA666933 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR12762975_1.fastq.gz	Fastqsanger.gz
	SRR12762975_2.fastq.gz	Fastqsanger.gz
	SRR12762976_1.fastq.gz	Fastqsanger.gz
	SRR12762976_2.fastq.gz	Fastqsanger.gz
	SRR12762977_1.fastq.gz	Fastqsanger.gz

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RNA-seq for UBR5-regulated genes in tumor associated macrophages

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RNA-seq for UBR5 and Cdc73-regulated genes in 4T1 cells treated with Dovitinib

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RNA-seq for UBR5 and Cdc73-regulated genes in 4T1 cells treated with Dovitinib

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Murine macrophages: Peritoneal exudate macrophages (PECs) vs tumor-associated macrophages (TAMs)

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UBR5 promotes antiviral immunity by disengaging the transcriptional brake on RIG-I like receptors

Project description:RIG-I like receptors (RLRs) are the major viral RNA sensors essential for the initiation of antiviral immune responses to numerous RNA viruses. RLRs are subjected to stringent transcriptional and posttranslational regulations, of which ubiquitination is one of the most important. However, the role of ubiquitination in RLR transcription is unknown. Here, we generated, screened 375 definite ubiquitin ligase knockout cell lines and identified UBR5 as a positive regulator of RLR transcription. UBR5 deficiency (UBR5-/-) reduced antiviral immune responses to RNA viruses, while increased viral replication in primary cells and mice. Ubr5-/- mice were more susceptible to lethal RNA virus infection than Ubr5+/+ littermates. Mechanistically, UBR5 mediated the Lysine 63-linked ubiquitination of TRIM28, an epigenetic repressor of RLRs. This modification prevented intramolecular SUMOylation of TRIM28, thus disengaged the TRIM28-imposed brake on RLR transcription. In sum, UBR5 enables rapid upregulation of RLR expression to boost antiviral immune responses by ubiquitinating and de-SUMOylating TRIM28.

2023-12-13 | GSE245604 | GEO

UBR5 promotes antiviral immunity by disengaging the transcriptional brake on RIG-I like receptors (RNA-Seq)

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UBR5 promotes antiviral immunity by disengaging the transcriptional brake on RIG-I like receptors (ChIP-Seq)

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Transcriptom analysis of FLT1 regulated genes in metastasis associated macrophages

Project description:Gene expression changes in metastasis associated macrophage (MAM) with control and FLT1 inhibitory antibody (MF1) were compared using FACS sorted cells from mice bearing pulmonary metastasis of breast tumor cells treated with Ctrl and MF1 antibody A six chip study using total RNA recovered from metastasis associated macrophages from three separate mice treated with FLT1 inhibitory antibody (MF1) and three separate mice treated with control antibody. Each chip measures the expression level of 42586 genes.

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Quantitative Analysis of Transcriptomes between Negative control, UBR5 depleted and MYC depleted HeLa cells

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2020-01-15 | GSE143517 | GEO

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