Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ABSTRACT: Identification of novel MeCP2 cancer-associated target genes

PROVIDER: PRJNA667107 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR12771437_1.fastq.gz	Fastqsanger.gz
	SRR12771437_2.fastq.gz	Fastqsanger.gz
	SRR12771438_1.fastq.gz	Fastqsanger.gz
	SRR12771438_2.fastq.gz	Fastqsanger.gz
	SRR12771439_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 44

Similar Datasets

Project description:Identification of novel DVL3 cancer-associated target genes

| PRJNA693700 | ENA

Identification of novel DVL3 cancer-associated target genes

Project description:Identification of novel DVL3 cancer-associated target genes

| PRJNA697865 | ENA

Identification of novel DVL3 cancer-associated target genes [RNA-seq]

Project description:Identification of novel DVL3 cancer-associated target genes [RNA-seq]

| PRJNA697868 | ENA

Identification of novel MeCP2 cancer-associated target genes and post-translational modifications

Project description:The goal of this study is to identify novel target genes of MeCP2 in two breast cancer cell lines.

2020-10-27 | GSE160150 | GEO

Mecp2: an unexpected regulator of macrophage gene expression and function [ChIP-Seq]

Project description:Mutations in methyl-CpG-binding protein 2 (MeCP2), a major epigenetic regulator, are the predominant cause of Rett syndrome. We previously found that Mecp2-null microglia are deficient in phagocytic ability, and that engraftment of wild-type monocytes into the brain of Mecp2-deficient mice attenuates pathology. We have observed that Mecp2 deficiency is associated with increased levels of histone acetylation at the cis-regulatory regions of the Mecp2-regulated genes in macrophages. We hypothesized that Mecp2 recruits protein complexes containing histone deacetylases (HDACs) to repress the expression of its target genes. Our ChIP-Seq studies in bone-marrow derived macrophages revealed that Mecp2 co-localizes with Ncor2/Hdac3 protein complex at cis-regulatory regions of the target genes. These results suggest a role for Mecp2 in the recruitment and regulation of Ncor2/Hdac3 repressosome that plays a critical role in the regulation of inflammatory responses in macrophages. Examination of NCOR2 and HDAC3 genome-wide location in bone-marrow derived macrophages.

2015-03-31 | E-GEOD-66501 | biostudies-arrayexpress

Mecp2: an unexpected regulator of macrophage gene expression and function [ChIP-Seq]

2015-03-31 | GSE66501 | GEO

Phosphorylation of MeCP2 at Serine 80 regulates its chromatin association and neurological function

Project description:Mutations of MECP2 (Methyl-CpG Binding Protein 2) cause Rett Syndrome. As a chromatin associated multifunctional protein, how MeCP2 integrates external signals and regulates neuronal function remain unclear. While neuronal activity-induced phosphorylation of MeCP2 at serine 421 (S421) has been reported, the full spectrum of MeCP2 phosphorylation together with the in vivo function of such modifications are yet to be revealed. Here we report the identification of several novel MeCP2 phosphorylation sites in normal and epileptic brains from multiple species. We demonstrate that serine 80 (S80) phosphorylation of MeCP2 is critical as its mutation into alanine (S80A) in transgenic knock-in mice leads to locomotor deficits. S80A mutation attenuates MeCP2 chromatin association at several gene promoters in resting neurons and leads to transcription changes of a small number of genes. Calcium influx in neurons causes dephosphorylation at S80, potentially contributing to its dissociation from the chromatin. We postulate that phosphorylation of MeCP2 modulates its dynamic function in neurons transiting between resting and active states within neural circuits that underlie behaviors. E 15.5 Mecp2 -/y cortical neurons were infected with lentivirus expressing wild-type and S80A mutant MeCP2 at similar protein expression level. 2 biological independent samples and dye swap were used for this set (GSM367413) and replicate 2 set (GSM367414).

2009-02-10 | E-GEOD-14715 | biostudies-arrayexpress

Phosphorylation of MeCP2 at Serine 80 regulates its chromatin association and neurological function

2009-02-10 | GSE14715 | GEO

Homo sapiens

Project description:Identification of LY6K target genes in bladder cancer

| PRJNA121903 | ENA

Identification of novel target genes for Nrf2 in Mytilus coruscus.

Project description:Identification of novel target genes for Nrf2 in Mytilus coruscus.

| PRJNA1013024 | ENA