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Expression data on lungs from Atf4wt/wt and Atf4D/D mice

ABSTRACT: Expression data on lungs from Atf4wt/wt and Atf4D/D mice

PROVIDER: PRJNA667429 | ENA |

REPOSITORIES: ENA

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Expression data on freshly isolated lungs from Atf4wt/wt and Atf4D/D mice.

Project description:Expression data on freshly isolated lungs from Atf4wt/wt and Atf4D/D mice.

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Expression data on freshly isolated lungs from Atf4wt/wt and Atf4D/D mice.

Project description:Since acute deletion of host ATF4 caused a significant tumor-inhibitory phenotype, and since activated CAFs also play a critical role in the establishment of the metastatic niche we speculated that ATF4 deficiency could also result in an inhibitory effect on lung metastasis. Thus, we examined the impact of host ATF4 deletion in the pre-metastatic niche by analyzing gene expression changes on lungs from Atf4wt/wt and Atf4D/D mice at 4 weeks post tamoxifen treatment. Genome-wide microarray analysis identified 21 genes to be significantly downregulated in Atf4D/D lungs, including collagen-associated genes. Also, pathway analysis on the most dysregulated genes revealed defects on collagen formation, extracellular matrix organization and integrin cell surface interactions pathways.

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2014-04-30 | GSE55403 | GEO

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2014-04-30 | E-GEOD-55403 | biostudies-arrayexpress

Expression data from SIRT6 knockout, young WT and old WT mice brains

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Expression and MeDIP microarray data from IL13-induced allergic airway inflammation of mice lungs

Project description:This SuperSeries is composed of the following subset Series: GSE35979: Gene expression data from IL13-induced allergic airway inflammation of mice lungs GSE35980: MicroRNA expression data from IL13-induced allergic airway inflammation of mice lungs GSE37079: Methylated DNA immunoprecipitation (MeDIP) microarray data from IL13-induced allergic airway inflammation of mouse lungs Refer to individual Series

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2010-12-31 | GSE20468 | GEO

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