Oncometabolism Drives Autophagy Activation in Skeletal Muscle
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ABSTRACT:
PROVIDER: PRJNA670469 | ENA |
REPOSITORIES: ENA
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2023-01-20 | GSE222885 | GEO
Project description:MYTHO: a novel regulator of skeletal muscle autophagy and integrity mRNA expression data for the mouse muscle (n=4 per group) were obtained using Affymetrix Mouse Clariom S Assay (Affymetrix, Santa Carla, CA) according to the manufacturer’s recommendations.
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2016-07-04 | E-GEOD-81096 | biostudies-arrayexpress
Project description:Utilizing glycerol intramuscular injections in M. musculus provide a models of skeletal muscle damage followed by skeletal muscle regeneration. In particular, glycerol-induced muscle injury triggers accute activation of skeletal muscle stem cells, called satellite cells. However, aging dramatically impairs the regenerative capacity of satellite cells. We characterized genome-wide expression profiles of young and old satellite cells in the non-proliferative and activated state, freshly isolated to non-injured or damaged muscles, respectively. Our goal was to uncover new regulatory signaling specific to satellite cells entry into the activation and myogenic program that are affected with age.
2016-07-04 | GSE81096 | GEO