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Dysregulation of brain and choroid plexus cell types in severe COVID-19

ABSTRACT: Dysregulation of brain and choroid plexus cell types in severe COVID-19

PROVIDER: PRJNA670674 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR12878700.fastq.gz	Fastqsanger.gz
	SRR12878701.fastq.gz	Fastqsanger.gz
	SRR12878682.fastq.gz	Fastqsanger.gz
	SRR12878683.fastq.gz	Fastqsanger.gz
	SRR12878684.fastq.gz	Fastqsanger.gz

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Dysregulation of brain and choroid plexus cell types in severe COVID-19

Project description:Though SARS-CoV-2 primarily targets the respiratory system, patients and survivors can suffer neurological symptoms. Yet, an unbiased understanding of the cellular and molecular processes affected in the brains of COVID-19 patients is still missing. Here, we profile 65,309 single-nucleus transcriptomes from 30 frontal cortex and choroid plexus samples across 14 control (including 1 terminal influenza) and 8 COVID-19 patients. While a systematic analysis yields no molecular traces of SARS-CoV-2 in the brain, we observe broad cellular perturbations which predict that choroid plexus barrier cells sense and relay peripheral inflammation into the brain and show that peripheral T cells infiltrate the parenchyma. We discover COVID-19 disease-associated microglia and astrocyte subpopulations that share features with pathological cell states reported in human neurodegenerative disease. Synaptic signaling of upper-layer excitatory neurons—evolutionarily expanded in humans and linked to cognitive function—are preferentially affected in COVID-19. Across cell types, COVID-19 perturbations overlap with those in chronic brain disorders and reside in genetic variants associated with cognition, schizophrenia, and depression. Our findings and public dataset provide a molecular framework to understand COVID-19 related neurological disease observed now and which may emerge later.

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