Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

CPEB4-mediated translational regulation of LPS response in BMDMs

ABSTRACT: CPEB4-mediated translational regulation of LPS response in BMDMs

PROVIDER: PRJNA672290 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR12905522.fastq.gz	Fastqsanger.gz
	SRR12905523.fastq.gz	Fastqsanger.gz
	SRR12905524.fastq.gz	Fastqsanger.gz
	SRR12905525.fastq.gz	Fastqsanger.gz
	SRR12905526.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 16

Similar Datasets

CPEB4-mediated translational regulation of LPS response in BMDMs

Project description:Here we show that the RNA-binding protein CPEB4 sustains the expression of anti-inflammatory factors in LPS-stimulated BMDMs, by binding to the corresponding mRNAs and promoting their stabilization. in macrophages.

2022-05-05 | GSE160191 | GEO

CPEB4-mediated translational regulation of LPS response in Bone Marrow Derived Macrophages (BMDMs)

Project description:Here we show the transcriptomic profile of the LPS response in BMDMs wild type and KO for the RNA-binding protein CPEB4.

2022-05-05 | GSE160246 | GEO

CPEB4-mediated translational regulation of LPS response in Bone Marrow Derived Macrophages (BMDMs)

Project description:CPEB4-mediated translational regulation of LPS response in Bone Marrow Derived Macrophages (BMDMs)

| PRJNA672706 | ENA

Cpeb4-mediated Translational Regulatory Circuitry Controls Terminal Erythroid Differentiation

Project description:Erythropoiesis is essential to mammals and is regulated at multiple steps by both extracellular and intracellular factors. Many transcriptional regulatory networks in erythroid differentiation have been well characterized. However, our understanding of post-transcriptional regulatory circuitries in this developmental process is still limited. Using genomic approaches, we identified a sequence-specific RNA-binding protein, Cpeb4, which is dramatically induced in terminal erythroid differentiation (TED) by two erythroid important transcription factors, Gata1/Tal1. Cpeb4 belongs to the cytoplasmic polyadenylation element binding (CPEB) protein family that regulates translation of target mRNAs in early embryonic development, neuronal synapse, and cancer. Using primary mouse fetal liver erythroblasts, we found that Cpeb4 is required for terminal erythropoiesis by repressing the translation of a set of mRNAs highly expressed in progenitor cells. This translational repression occurs by the interaction with a general translational initiation factor, eIF3. Interestingly, Cpeb4 also binds its own mRNA and represses its translation, thus forming a negative regulatory circuitry to limit Cpeb4 protein level. This mechanism ensures that the translation repressor, Cpeb4, does not interfere with the translation of other mRNAs in differentiating erythroblasts. Our study characterized a translational regulatorycircuitry that controls TED and revealed that Cpeb4 is required for somatic cell differentiation. We used microarray to identify mRNAs associated with Cpeb4 in mouse fetal liver erythroblasts. Cpeb4 associated mRNAs were isolated from mouse fetal liver erythroblasts using anti-Cpeb4 antibody for immunoprecipitation followed by RNA extraction. Then Affymetrix microarrays were used to identify and quantify the mRNAs associated with Cpeb4.

2015-12-09 | E-GEOD-57004 | biostudies-arrayexpress

Cpeb4-mediated Translational Regulatory Circuitry Controls Terminal Erythroid Differentiation

2015-12-09 | GSE57004 | GEO

CPEB4-mediated translational regulation in ex vivo activated CD8 Tcells

Project description:CPEB4-mediated translational regulation in ex vivo activated CD8 Tcells

| PRJNA784433 | ENA

Global mRNA translational landscapes in mouse bone-marrow-derived-macrophage-mediated response to LPS (lipopolysaccharide)

Project description:We performed ribosome profiling and RNA-seq on mouse bone marrow derived macrophages (BMDMs) treated with 100ng/ml LPS for 0hr, 1hr, 2hrs, 4hrs, 6hrs to obtain global mRNA translational landscapes during this inflammatory response.

2017-07-11 | GSE99787 | GEO

CPEB4-mediated translational regulation in ex vivo activated CD8 Tcells [RNA-seq]

Project description:Here we show the transcriptomic profile of resting and activated CD8 wild-type and KO for CPEB4

2023-02-06 | GSE189592 | GEO

CPEB4-mediated translational regulation in ex vivo activated CD8 Tcells [RIP-seq]

Project description:Here we show that CPEB4 preferably binds targets related to UPR and anaolic pathways in activated CD8 T cells

2023-02-06 | GSE189765 | GEO

CPEB4-mediated translational regulation in ex vivo activated CD8 Tcells [RIP-seq]

Project description:CPEB4-mediated translational regulation in ex vivo activated CD8 Tcells [RIP-seq]

| PRJNA784439 | ENA