Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Vascular and perivascular cell profiling reveals the molecular and cellular bases of blood-brain barrier heterogeneity [scRNA-Seq]

ABSTRACT: Vascular and perivascular cell profiling reveals the molecular and cellular bases of blood-brain barrier heterogeneity [scRNA-Seq]

PROVIDER: PRJNA673433 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Vascular and perivascular cell profiling reveals the molecular and cellular bases of blood-brain barrier heterogeneity

Project description:Vascular and perivascular cell profiling reveals the molecular and cellular bases of blood-brain barrier heterogeneity

| PRJNA1006720 | ENA

Vascular and perivascular cell profiling reveals the molecular and cellular bases of blood-brain barrier heterogeneity [GEOMx]

Project description:Vascular and perivascular cell profiling reveals the molecular and cellular bases of blood-brain barrier heterogeneity [GEOMx]

| PRJNA1006713 | ENA

Vascular and perivascular cell profiling reveals the molecular and cellular bases of blood-brain barrier heterogeneity [GEOMx]

Project description:Nanostring GeoMX Whole Transcriptome Analysis performed on pericyte- and perivascular fibroblast-enriched areas of interest in the cortex and median eminence of the mouse brain

2024-07-23 | GSE241199 | GEO

Vascular and perivascular cell profiling reveals the molecular and cellular bases of blood-brain barrier heterogeneity

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-07-23 | GSE241206 | GEO

Vascular and perivascular cell profiling reveals the molecular and cellular bases of blood-brain barrier heterogeneity [scRNA-Seq]

Project description:Single cell (inDrops) RNA sequencing analysis of median eminence and somatosensory cortex in male, wild type mice

2024-07-23 | GSE160519 | GEO

RNA-seq of human U87MG-GFP perivascular glioma stem cells

Project description:Glioblastoma stem cells (GSCs) have been reported to be found near the blood vessels. We wanted to identify the perivascular GSCs by combining the label retention approach with vascular perfusion. GSCs, like most of the stem cells, are in a quiescent state. Label retention approach involves staining the cells with a uniform membrane labeling dye (PKH26) and allowing them to grow in vivo in NOD SCID mice. Slow-dividing stem cells will retain the dye to a greater extent and perivascular cells are identified by injecting the mice with vascular perfusion dye (Hoechst 33342) 5 min prior to sacrifice. Perivascular GSCs (positive for Hoechst 33342 and pKH26 dye - dubbed as H+P+) were compared with the rest of the perivascular glioma cells (H+P-).

2022-01-01 | E-MTAB-9607 | biostudies-arrayexpress

Single-cell view and a novel protective macrophage subset in perivascular adipose tissue (PVAT) in T2DM

Project description:Reveal the single-cell landscape of the stromal vascular fraction (SVF) of perivascular adipose tissue (PVAT) and show its tremendous heterogeneity and significant alterations in type 2 diabetes.

2024-08-27 | GSE275779 | GEO

PARP15 promotes vascular barrier integrity in inflammation

Project description:The vascular endothelial barrier, which supports balanced plasma solute and macromolecule composition, controls hemostasis, and limits leukocyte extravasation at homeostasis, is frequently disrupted in inflammation associated with sepsis and other critical illness. Monoclonal gammopathy-associated idiopathic systemic capillary leak syndrome (ISCLS, Clarkson disease) is a rare and devastating disorder characterized by relapsing-remitting episodes of spontaneous, profound microvascular hyper-permeability. A loss of function (LOF) mutation (G628R) in the mono ADP-ribosyltransferase PARP15, a protein of unknown function that is absent in mice, is associated with ISCLS and correlates with clinical markers of severe vascular leakage. In vascular endothelial cells, PARP15 suppresses cytokine-induced barrier disruption by ADP-ribosylating the scaffold protein JNK-interacting protein 3 (JIP3) and inhibiting p38 MAP kinase activation. Mice expressing human wild type (WT) PARP15 have curtailed inflammation-associated vascular leakage compared to mice expressing PARP15(G628R) in a p38-dependent fashion. Thus, PARP15 is essential for vascular endothelial barrier function under inflammatory stress.

2024-06-29 | GSE236167 | GEO

PARP15 promotes vascular barrier integrity in inflammation

Project description:PARP15 promotes vascular barrier integrity in inflammation

| PRJNA989163 | ENA

Beiging of perivascular adipose tissue regulates its inflammation and vascular remodeling

Project description:Although inflammation plays critical roles in the development of atherosclerosis, its regulatory mechanisms remain incompletely understood. Perivascular adipose tissue (PVAT) has been reported to undergo inflammatory changes in response to vascular injury. Here, we showed that vascular injury induced the beiging (brown adipose tissue-like phenotype change) of PVAT, which fine-tunes inflammatory response and thus vascular remodeling as a protective mechanism. In a mouse model of endovascular injury, macrophages accumulated in PVAT, causing beiging phenotype change. Inhibition of PVAT beiging by genetically silencing PRDM16, a key regulator to beiging, exacerbated inflammation and vascular remodeling following injury. Conversely, activation of PVAT beiging attenuated inflammation and pathological vascular remodeling. Single-cell RNA sequencing revealed that beige adipocytes abundantly expressed neuregulin 4 (Nrg4) which critically regulated alternative macrophage activation. Importantly, significant beiging was observed in the diseased aortic PVAT in patients with acute aortic dissection. Taken together, vascular injury induced the beiging of adjacent PVAT with macrophage accumulation, where NRG4 secreted from the beige PVAT facilitated alternative activation of macrophages, leading to the resolution of vascular inflammation. Our study demonstrated the pivotal roles of PVAT in vascular inflammation and remodeling and will open a new avenue for treating atherosclerosis.

2022-06-21 | GSE206399 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data