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Identification of transcriptional difference between platinum-sensitive and resistant patients with ovarian cancer (OV)

ABSTRACT: Identification of transcriptional difference between platinum-sensitive and resistant patients with ovarian cancer (OV)

PROVIDER: PRJNA673814 | ENA |

REPOSITORIES: ENA

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Identification of transcriptional difference between platinum-sensitive and resistant patients with ovarian cancer (OV)

Project description:Purpose: The goals of this study are to characterize the transcriptional dysregulation of OV. More importantly, the transcriptome differences betweeen platinum-sensitive and resistant patients are compared to identify RNAs that may impact platinum resistance. Methods: High-throughput RNA sequencing (RNA-seq) was employed to capture the transcriptional changes in OV compared to normal samples. StringTie was used to quantify gene expression and DESeq2 was utilized to compared expression changes between different sample groups.

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Project description:Resistance to platinum compounds represents a major obstacle to the cure of ovarian carcinoma. The molecular profiling of drug-sensitive and drug-resistant cells may be helpful to clarify if altered expression of miRNAs can contribute to the drug-resistant phenotype. The expression pattern of miRNAs of three ovarian carcinoma cell lines was examined. The analysis revealed the modulation of several miRNAs in the two platinum-resistant cell lines as compared to parental platinum-sensitive cells. The integration of the information obtained through miRNA expression analysis may be useful to clarify the specific molecular alterations of factors and pathway favouring survival of tumor cells.

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Project description:Resistance to platinum compounds represents a major obstacle to the cure of ovarian carcinoma. The molecular profiling of drug-sensitive and drug-resistant cells may be helpful to clarify if altered gene expression can contribute to the drug-resistant phenotype. The expression pattern of three ovarian carcinoma cell lines was examined. The analysis revealed the modulation of several genes in the two platinum-resistant cell lines as compared to parental platinum-sensitive cells. The integration of the information obtained through gene expression analysis may be useful to clarify the specific molecular alterations of factors and pathway favouring survival of tumor cells.

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Proteomics of 58 platinum-sensitive and 30 platinum-resistant ovarian cancer tissue-derived exosomes

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