Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Expression profiling of Setleis vs Control lymphoblastoid cells

ABSTRACT: Expression profiling of Setleis vs Control lymphoblastoid cells

PROVIDER: PRJNA674787 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Expression profiling of Setleis vs Control lymphoblastoid cells

Project description:Background: Setleis Syndrome (SS) is a rare focal facial dermal dysplasia frequently found in Puerto Ricans, presenting with bilateral temporal skin lesions, eyelash abnormalities and absent meibomian glands. SS is caused by homozygous mutations in the TWIST2 gene, which codes for a transcription factor of the bHLH family known to be involved in skin and facial development. Methods: We obtained gene expression profiles by microarray analyses from control and Setleis Syndrome patient primary skin fibroblast and lymphoblastoid cell lines. Results: Out of 983 differentially regulated genes in fibroblasts, 479 were down-regulated and 504 were up-regulated, while in lymphoblasts a greater number of differentially regulated genes (1248 down-regulated and 73 up-regulated) were found after microarray analysis. Real time PCR reactions confirmed altered expression of several differentially regulated genes. Conclusion: TWIST2 is described as a repressor, but expression profiling indicates it has a role in gene activation, as evidenced by the much higher proportion of down-regulated genes in cells from SS patients, including cytokine genes, in fibroblasts, the top three networks involved genes that function in Cancer, Nervous System Development and Function, Lipid Metabolism, Molecular Transport and Organismal Injury and Abnormalities. In Lymphoblastoid cells, the top three networks involved genes in Endocrine System Disorders, Cell Cycle, Cellular Assembly and Organization, Cardiovascular Disease and Developmental Disorders

2020-11-06 | GSE160893 | GEO

Gene expression profiling of HCCLM3 cells: Control ASO vs SCARNA13 ASO

Project description:Gene expression profiling of HCCLM3 cells: Control ASO vs SCARNA13 ASO

| PRJNA491641 | ENA

RNA-Seq profiling of LAQ vs Control mice

Project description:RNA-Seq profiling of LAQ vs Control mice

| PRJNA605789 | ENA

1833 cells expressing RKIP vs control

Project description:1833 cells expressing RKIP vs control

| PRJNA205363 | ENA

Vector Control vs SNAIL vs SNAIL/FBXO11

Project description:Vector Control vs SNAIL vs SNAIL/FBXO11

| PRJNA219288 | ENA

Epigenome analysis of control and neurodevelopmental disorder lymphoblastoid cell lines

Project description:Genome wide DNA methylation profiling of control and neurodevelopmental disorder lymphoblastoid cell lines (LCL). The Illumina Infinium 27k Human DNA methylation Beadchip v1.2 was used to obtain DNA methylation profiles across approximately 27,000 CpGs in LCLs. Samples included 19 control, 18 Rett syndrome, 17 autism and 6 generalized epilepsy LCL samples. Six technical replicates were also included in the analysis.

2012-12-01 | GSE34099 | GEO

Transcription profiling of human lymphoblastoid cells from control males without autism

Project description:gene expression profiles of lymphoblastoid cells from control males without autism Experiment Overall Design: Cy5; each control male Experiment Overall Design: Cy3; pool of 14 unrelated individuals.

2008-06-15 | E-GEOD-7317 | biostudies-arrayexpress

Burkitt lymphoma cells vs. Lymphoblastoid B cells

Project description:To identify genes mediating tumor transformation we compared the transcriptome of five Burkitt lymphoma (BL) cell lines (tumor cells) with that of a pool of three lymphoblastoid B-cell lines (LCL; immortal, but not tumor cells). Each BL cell line was considered as a biological replicate. BL cell lines: DG-75, Ramos, BL2, Mutu-I and Akata. LCL cell lines: X50-7, IB4 and Dana.

2015-09-30 | GSE41865 | GEO

ESCC KYSE150 cells: TPA treatment vs. control

Project description:ESCC KYSE150 cells: TPA treatment vs. control

| PRJNA703987 | ENA

Fission yeast cells: control vs alkaline stress

Project description:Fission yeast cells: control vs alkaline stress

| PRJNA509425 | ENA