MiR-33 silencing reprograms the immune cell landscape in atherosclerotic plaques
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA678449 | ENA |
REPOSITORIES: ENA
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| SRR13061309_1.fastq.gz | Fastqsanger.gz | |||
| SRR13061309_2.fastq.gz | Fastqsanger.gz | |||
| SRR13061310_1.fastq.gz | Fastqsanger.gz | |||
| SRR13061310_2.fastq.gz | Fastqsanger.gz |
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Project description:Inhibition of miR-33 results in increased cholesterol efflux and HDL-cholesterol levels in mice. In this study we examined the effect of miR-33 inhibition in a mouse model of atherosclerosis and observed significant reduction in atherosclerotic plaque size. At the end of the study, gene expression in macrophages from the atherosclerotic plaques was assessed. The results demonstrated a reduction in inflammatory gene expression and increased levels of mRNAs containing miR-33 binding sites.
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