Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Human gut metagenome

ABSTRACT: Shotgun metagenomic sequencing of stool samples from two South African cohorts

PROVIDER: PRJNA678454 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR13061700.fastq.gz	Fastqsanger.gz
	SRR13061701.fastq.gz	Fastqsanger.gz
	SRR13061702.fastq.gz	Fastqsanger.gz
	SRR13061703.fastq.gz	Fastqsanger.gz
	SRR13061704.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 168

Similar Datasets

human gut metagenome

Project description:Metagenomics of African Stool Samples

| PRJNA203312 | ENA

human gut metagenome

Project description:Microbiome of African Stool Samples

| PRJNA201339 | ENA

Altered fecal small RNA profiles in colorectal cancer reflect gut microbiome composition in stool samples

Project description:Dysbiotic configurations of the human gut microbiota have been linked with colorectal cancer (CRC). Human small non-coding RNAs are also implicated in CRC and recent findings suggest that their release in the gut lumen contributes to shape the gut microbiota. Bacterial small RNAs (bsRNAs) may also play a role in carcinogenesis but their role is less explored. Here, we performed small RNA and shotgun sequencing on 80 stool specimens of patients with CRC, or adenomas, and healthy subjects collected in a cross-sectional study to evaluate their combined use as a predictive tool for disease detection. We reported a considerable overlap and correlation between metagenomic and bsRNA quantitative taxonomic profiles obtained from the two approaches. Furthermore, we identified a combined predictive signature composed by 32 features from human and microbial small RNAs and DNA-based microbiome able to accurately classify CRC from healthy and adenoma samples (AUC= 0.87). In summary we reported evidence that host-microbiome dysbiosis in CRC can be observed also by altered small RNA stool profiles. Integrated analyses of the microbiome and small RNAs in the human stool may provide insights for designing more accurate tools for diagnostic purposes.

2019-08-30 | GSE132236 | GEO

H3Africa ReMAC Shotgun Metagenomic

Project description:Shotgun metagenomic sequencing data for nasopharyngeal colonization dynamics with Streptococcus pneumoniae and associated antimicrobial-resistance in a South African birth cohort.

| EGAD00001006244 | EGA

Development and validation of a microarray for the investigation of the CAZymes encoded by the human gut microbiome

Project description:Distal gut bacteria play a pivotal role in the digestion of dietary polysaccharides by producing a large number of carbohydrate-active enzymes (CAZymes) that the host otherwise does not produce. We report here the design of a high density custom microarray that we used to spot non-redundant DNA probes for more than 6,500 genes encoding glycoside hydrolases and lyases selected from 174 reference genomes from distal gut bacteria. The custom microarray was tested and validated by the hybridization of bacterial DNA extracted from the stool samples of lean, obese and anorexic individuals. Our results suggest that a microarray-based study can detect genes from low-abundance bacteria better than metagenomic-based studies. A striking example was the finding that a gene encoding a GH6-family cellulase was present in all subjects examined, whereas metagenomic studies have consistently failed to detect this gene in both human and animal gut microbiomes. In addition, an examination of eight stool samples allowed the identification of a corresponding CAZome core containing 46 families of glycoside hydrolases and polysaccharide lyases, which suggests the functional stability of the gut microbiota despite large taxonomical variations between individuals.

2013-10-28 | GSE51760 | GEO

Zearalenone-induced aberration in gut microbiome composition and function are associated with degeneration in ovary reserve

Project description:We applied metagenomic shotgun sequencing to investigate the effects of ZEA exposure on the change of mouse gut microbiota composition and function.

2019-11-09 | GSE140149 | GEO

Development and validation of a microarray for the investigation of the CAZymes encoded by the human gut microbiome

2013-10-28 | E-GEOD-51760 | biostudies-arrayexpress

human gut metagenome

Project description:Metagenomic sequencing of stool samples from Ghanaian individuals

| PRJNA529124 | ENA

Differences in gut microbiota and its metabolic function among different fasting plasma glucose groups in Mongolian population of China

Project description:We recruited 24 Mongolian volunteers,6 of which were T2D cases(sample T1-T6), 6 were prediabetes cases(sample P1-P6), and 12 were health cases(sample C1-C12). The metagenomic analysis of gut microbiota from the volunteers’ fecal samples was performed. We compared the microbial differences in the three groups, and analyzed the differences of the stool microbial function.

2022-07-30 | E-MTAB-11957 | biostudies-arrayexpress

human gut metagenome

Project description:Microbiome analysis of stool samples from African Americans with colon polyps

| PRJNA222611 | ENA