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Gene expression profiling of sarcoma cells treated with mithramycin A (MTA), nano-encapsulated MTA or MTA-analogs

ABSTRACT: Gene expression profiling of sarcoma cells treated with mithramycin A (MTA), nano-encapsulated MTA or MTA-analogs

PROVIDER: PRJNA678952 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR13073037_1.fastq.gz	Fastqsanger.gz
	SRR13073037_2.fastq.gz	Fastqsanger.gz
	SRR13073038_1.fastq.gz	Fastqsanger.gz
	SRR13073038_2.fastq.gz	Fastqsanger.gz
	SRR13073039_1.fastq.gz	Fastqsanger.gz

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Gene expression profiling of sarcoma cells treated with mithramycin A (MTA), nano-encapsulated MTA or MTA-analogs

Project description:This study was designed to gain insight about the mechanisms involved in the anti-tumor effects of mithramycin A (MTA) and the MTA analog EC-8042 in sarcoma cells. In addition, we also studied whether this molecular features could be influenced by the nano-encapsulation of MTA.

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Project description:Mithramycin A in known to bind DNA but its exact cellular mechanism of action is still unclear. We used Affymatrix GenFlex_Tag_16K_V2 microarrays to profile sensitivity of genetically barcoded S. cerevisiae gene deletion strains to mithramycin A

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Ewing Sarcoma cell lines treated with mithramycin

Project description:The study aims to define gene expression changes associated with mithramycin treatment of Ewing Sarcoma cell lines. The data consist of 12 arrays. Two cell lines, TC71 and TC32, were treated with solvent control or with mithramycin, and RNA was extracted at 6 hours. Three biological replicates per cell line/treatment.

2011-04-18 | E-GEOD-25127 | biostudies-arrayexpress

Mithramycin A chemogenomic profile

Project description:Mithramycin A chemogenomic profile

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Ewing Sarcoma cell lines treated with mithramycin

Project description:The study aims to define gene expression changes associated with mithramycin treatment of Ewing Sarcoma cell lines.

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Project description:We used microarrays to detail the global gene expression of mithramycin treated cells, xenografts and sp1 depleted cells with p53 overexpression. MPM cells and xenografts were treated with mithramycin or SP1 depleted/p53 overexpressed MPM cells were selected for RNA extraction and hybridization on Affymetrix microarrays. We sought to see the invitro and invivo effect of mithramycin (pharmacological model) and depletion of SP1 and overexpression of p53 (genetic model).

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