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Gene expression in activated WT or PDK4 -/- CD4+ T cells

ABSTRACT: Gene expression in activated WT or PDK4 -/- CD4+ T cells

PROVIDER: PRJNA679025 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR13075303.fastq.gz	Fastqsanger.gz
	SRR13075304.fastq.gz	Fastqsanger.gz
	SRR13075305.fastq.gz	Fastqsanger.gz
	SRR13075306.fastq.gz	Fastqsanger.gz

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Gene expression in activated WT or PDK4 -/- CD4+ T cells

Project description:Activation of CD4+ T cells requires metabolic reprograming to sustain demands of cellular building blocks and ATP. Pyruvate dehydrogenase kinase (PDK) is an enzyme regulating pyruvate dehydrogenase complex subunit alpha 1 (PDHE1-alpha), which converts pyruvate to acetyl-CoA. Gene expression analysis of TCR-stimulated CD4+ T cells with PDK4 deletion exhibited the reduced calcium signaling and aerobic glycolysis pathway.

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Project description:CD4 T cell deficient for the Elp3 gene have a delayed cell cycle entry. We explored by RNAseq by which molecular pathway the absence of Elp3 delayed the cell cycle entry. Naive T cell from CD4-cre Elp3 fl/fl mice and WT littermate were purified and activated in vitro with CD3 and CD28 antibodies for 18h.

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