Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Profiling of indolent and aggressive mammary lesions

ABSTRACT: Profiling of indolent and aggressive mammary lesions

PROVIDER: PRJNA680303 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR13114355_1.fastq.gz	Fastqsanger.gz
	SRR13114355_2.fastq.gz	Fastqsanger.gz
	SRR13114356_1.fastq.gz	Fastqsanger.gz
	SRR13114356_2.fastq.gz	Fastqsanger.gz
	SRR13114357_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 46

Similar Datasets

Transcriptional profiling of indolent and aggressive mammary lesions

Project description:Transcriptional profiling of indolent and aggressive mammary lesions

| PRJNA680306 | ENA

Transcriptional profiling of indolent and aggressive mammary lesions

Project description:We performed transcriptional profiling of tumor cells from indolent and aggressive lesions isolated from a mouse model of breast cancer. To initiate formation of mammary lesions, we delivered lentiviral particles carrying constitutively-activated Erbb2 tagged with HA and GFP (caErbB2) through the lactiferous glands of adult virgin female. Mammary glands bearing lesions were visualized under a fluorescence stereoscope, and regions harboring aggressive (>2mm, comprised of invasive lesions) and indolent (<2mm, enriched for in situ lesions) lesions were dissected away from each other. Lesions from multiple animals were pooled to obtain sufficient material for downstream analysis. Following tissue digestion, GFP-expressing epithelial cells were isolated by fluorescence-activated cell sorting (FACS), and then subjected to bulk RNA-seq.

2021-06-17 | GSE162005 | GEO

Single-cell transcriptional profiling of indolent and aggressive mammary lesions

Project description:We performed transcriptional profiling of tumor cells from indolent and aggressive lesions isolated from a mouse model of breast cancer. To initiate formation of mammary lesions, we delivered lentiviral particles carrying constitutively-activated Erbb2 tagged with HA and GFP (caErbB2) through the lactiferous glands of adult virgin female. Mammary glands bearing lesions were visualized under a fluorescence stereoscope, and regions harboring aggressive (>2mm, comprised of invasive lesions) and indolent (<2mm, enriched for in situ lesions) lesions were dissected away from each other. Lesions from multiple animals were pooled to obtain sufficient material for downstream analysis. Following tissue digestion, GFP-expressing epithelial cells and CD45+ immune cells were isolated by fluorescence-activated cell sorting (FACS), and then subjected to single-cell RNA-sequencing.

2021-06-17 | GSE161983 | GEO

Single-cell transcriptional profiling of indolent and aggressive mammary lesions

Project description:Single-cell transcriptional profiling of indolent and aggressive mammary lesions

| PRJNA680255 | ENA

Profiling of indolent and aggressive mammary lesions

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-06-17 | GSE162006 | GEO

Transcription profiling of human indolent and aggressive forms of Chronic Myeloid Leukaemia (CML)

Project description:Title: Gene expression analysis of indolent and aggressive forms of Chronic Myeloid Leukaemia (CML). Description: Chronic Myeloid Leukaemia presents in chronic phase (CP) and terminates in 'blast crisis'. Despite a common abnormality, the duration of CP is variable. The aim is to compare the gene expression profiles of the indolent and aggressive forms of CML. All samples were taken within 3 months of first diagnosis. Indolent patients were defined by chronic phase CML, duration minimum 7 years. Aggressive patients were defined by chronic phase, duration maximum 3 years.

2013-01-30 | E-MIMR-17 | biostudies-arrayexpress

Indolent MCL identified by genomic and gene expression profiling

2010-03-04 | GSE16455 | GEO

Transcription profiling by array of human indolent mantle cell lymphoma

Project description:Mantle cell lymphoma (MCL) is an aggressive neoplasm with poor outcome. However, some patients have an indolent disease (iMCL) and may not require intensive treatment at initial diagnosis. Diagnostic criteria to recognize these patients are not available. We hypothesized that the analysis of the genetic and expression features of the tumors may help to identify patients with an indolent clinical evolution and provide biomarkers that could be used in the clinical setting. Seven patients with an iMCL that did not require chemotherapy for more than 2 years were compared to 15 conventional MCL (cMCL) that needed systemic therapy at diagnosis. MCL were compared with other leukemic lymphoid neoplasms including 17 CLL, 7FL, HCL and 2HCLv.

2010-03-04 | E-GEOD-16455 | biostudies-arrayexpress

The use of tissue microRNAs to distinguish indolent and aggressive forms of prostate cancer

Project description:The use of tissue microRNAs to distinguish indolent and aggressive forms of prostate cancer

| PRJNA837190 | ENA

Transcriptomic profiling of dermatomyositis lesions.

Project description:Transcriptomic profiling of dermatomyositis lesions.

| PRJNA598373 | ENA