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Transcriptome of human monocyte-derived macrophages infected with live-Mycobacterium leprae

ABSTRACT: Transcriptome of human monocyte-derived macrophages infected with live-Mycobacterium leprae

PROVIDER: PRJNA681824 | ENA |

REPOSITORIES: ENA

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Transcriptome of human monocyte-derived macrophages infected with live-Mycobacterium leprae

Project description:To this date, host transcriptome studies in leprosy have focused on Schwann cells, as well as mouse-footpad and skin biopsies. Despite macrophages being the most infected cell types in leprosy lesions, there is no genome-wide experiments with this model. Here, we aimed at identifying host macrophages transcriptional changes induced by live-Mycobacterium leprae infection for 48 hours.

2021-04-16 | GSE162416 | GEO

Comparison of Gene expression pattern between heat-killed M.leprae and live M. leprae-infected peritoneal macrophage in vivo model

Project description:Our goal is to discriminate specific genes in live M.leprae-infected peritoneal macrophages in comparison to heat-killed M.leprae infected peritoneal macrophages using microarray. Two-condition experiment, Heat-killed M.leprae infected macrophage vs. Live M.leprae infected macrophage. Biological replicates: 16 mice (control), 8 heat-killed M. leprae mice (sample 1), and 8 live M. leprae infected mice (sample 2). Independently grown and harvested from isolator. One replicate per array.

2011-03-17 | E-GEOD-23749 | biostudies-arrayexpress

Transcriptome analysis in Mycobacterium leprae (M. leprae)-infected granuloma of BALB/c nu/nu mice

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Transcriptome analysis in Mycobacterium leprae (M. leprae)-infected granuloma of BALB/c nu/nu mice

Project description:Our object is to characterize the distinguish gene enrichment group in skin of Mycobacterium leprae (M. leprae)-infected footpads compared to that of Mycobacterium leprae (M. leprae) non-infected footpads. One-condition experiment, Skin of M. leprae non-infected footpads (control) vs. Skin of M. leprae infected footpads (sample). Biological replicates: 3 control and 3 sample, independently grown and harvested from isolator. One replicate per array.

2011-03-17 | E-GEOD-24120 | biostudies-arrayexpress

Profiling of Gene expression in Mycobacterium leprae (M. leprae)-infected footpad of BALB/c nu/nu mice

Project description:Our goal is to understand the mechanism of granuloma formation in molecular level using Mycobacterium leprae (M. leprae)-infected footpads.

2011-03-17 | GSE22784 | GEO

Profiling of Gene expression in Mycobacterium leprae (M. leprae)-infected footpad of BALB/c nu/nu mice

Project description:Our goal is to understand the mechanism of granuloma formation in molecular level using Mycobacterium leprae (M. leprae)-infected footpads. One-condition experiment, M. leprae non-infected footpads (control) vs. M. leprae infected footpads (sample). Biological replicates: 6 control, 6 (sample), independently grown and harvested from isolator. One replicate per array.

2011-03-17 | E-GEOD-22784 | biostudies-arrayexpress

Effect of live Mycobacterium leprae on primary human Schwann cell gene expression

Project description:In attempt to understand M.leprae interaction with the human host, Applied Biosystems microarrays containing 30,865 probles were used to identify modulated genes in primary human Schwann Cells (SC) infected with live M. leprae at two early time points, 24 and 48 hours. A total of 4 independent experimental samples were prepared which were hybridized to two replicate microarrays each.The four experimental samples included both uninfected and M. leprae infected Schwann cells at both 24 and 48 hours.

2012-06-30 | E-GEOD-35423 | biostudies-arrayexpress

Effect of live Mycobacterium leprae infection on global gene expression of primary human Schwann cells at 24 hours

2013-01-03 | GSE40950 | GEO

Effect of live Mycobacterium leprae on primary human Schwann cell gene expression

2012-07-01 | GSE35423 | GEO

Effect of live Mycobacterium leprae infection on global gene expression of primary human Schwann cells at 24 hours

Project description:In an attempt to understand M. leprae interaction with the human host, Stanford Genomics HEEBO Arrays were use to identify modulated genes in primary human Schwann cells infected with live M. leprae at a MOI of 100:1 for 24 hours. Dual channel competitive hybridizations between M. leprae infected and non infected Schwann cells including 3 independent biological replicates and a technical replicate in the form of dye swap.

2013-01-03 | E-GEOD-40950 | biostudies-arrayexpress

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