Plasma-derived exosomes boost the healing of irradiated wound by regulating cell proliferation and ferroptosis
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA682748 | ENA |
REPOSITORIES: ENA
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| SRR13202238.fastq.gz | Fastqsanger.gz | |||
| SRR13202239.fastq.gz | Fastqsanger.gz | |||
| SRR13202240.fastq.gz | Fastqsanger.gz | |||
| SRR13202241.fastq.gz | Fastqsanger.gz | |||
| SRR13202242.fastq.gz | Fastqsanger.gz |
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Project description:Extracellular vesicles (EVs) are on the edge of innovation aimed at regenerative and therapeutic applications, including wound healing, by containing therapeutic agents originating from secreting cells. Moreover, silver nanoparticles (AgNPs) play a role in wound healing because they have antiseptic activities. Therefore, in this study, we used sequencing technology to investigate the mRNA profile in UCMSC-derived exosomes (EXs). We also attempted to determine the role of the transcriptome, particularly in cutaneous wound healing, using bioinformatics analysis. Additionally, we investigated the efficacy of utilising a combination of UCMSC-derived EXs and AgNPs on burned animal models. Results showed that a large number of protein-coding genes (4578 genes) have been detected in UCMSC-derived EXs, among which 2004 genes are upregulated in exosomes while 2574 genes are downregulated compared to secreting cells. 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