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16S V3-V4 -based microbial profiling of matched healthy and inflamed ileal mucosa from patients affected by Crohn’s disease

ABSTRACT: 16S V3-V4 -based microbial profiling of matched healthy and inflamed ileal mucosa from patients affected by Crohn’s disease

PROVIDER: PRJNA683584 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR13216200_1.fastq.gz	Fastqsanger.gz
	SRR13216200_2.fastq.gz	Fastqsanger.gz
	SRR13216201_1.fastq.gz	Fastqsanger.gz
	SRR13216201_2.fastq.gz	Fastqsanger.gz
	SRR13216202_1.fastq.gz	Fastqsanger.gz

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16S V3-V4 -based microbial profiling of matched healthy and inflamed ileal mucosa from patients affected by Crohn’s disease

Project description:Crohn’s Disease (CD) pathogenesis is still unclear. Disorders in the mucosal immunoregulation and its crosstalk with the microbiota may represent an important component in tissue injury. We aimed to characterize the molecular immune response distribution within the ileal layers ( mucosa, submucosa and serosa) and to evaluate the correlated microbiota in pathological/healthy settings comparing first surgery/relapse clinical conditions.

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Project description:16S V3-V4 -based microbial profiling of matched healthy and inflamed ileal mucosa from patients affected by Crohn’s disease (set 2)

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Ileal Crohn’s disease exhibits reduced activity of phospholipase C-β3 (PLC-β3)-dependent Wnt/b-catenin signaling pathway [ATAC-Seq]

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