Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Single cell analysis of senescent cells of old p16-FDR mice (kidney)

ABSTRACT: Single cell analysis of senescent cells of old p16-FDR mice (kidney)

PROVIDER: PRJNA683860 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Single cell analysis of senescent cells of old p16-FDR mice (kidney)

Project description:We report the analysis of single cell based sequencing to understand the cellular and molecular heterogeneity of senescent cell populations in vivo in multiple organ types. The findings will help characterise the roles different cell types play during the aging process.

2022-12-10 | GSE162923 | GEO

Single cell analysis of senescent cells of old p16-FDR mice (heart)

Project description:Single cell analysis of senescent cells of old p16-FDR mice (heart)

| PRJNA683861 | ENA

Single cell analysis of senescent cells of old p16-FDR mice (lung)

Project description:Single cell analysis of senescent cells of old p16-FDR mice (lung)

| PRJNA683865 | ENA

Single cell analysis of senescent cells of old p16-FDR mice (heart)

2022-12-10 | GSE162922 | GEO

Single cell analysis of senescent cells of old p16-FDR mice (lung)

2022-12-10 | GSE162921 | GEO

p16-dependent upregulation of PD-L1 impairs immunosurveillance of senescent cells [RNA-seq: Lung Epithelial Cells]

Project description:The accumulation of senescent cells promotes aging, but a molecular mechanism that senescent cells use to evade immune clearance and accumulate remains to be elucidated. Here, we report that p16-positive senescent cells upregulate the immune checkpoint protein programmed death-ligand 1 (PD-L1) to accumulate in aging and chronic inflammation. p16-mediated inhibition of CDK4/6 promotes PD-L1 stability in senescent cells via the downregulation of ubiquitin-dependent degradation. p16 expression in infiltrating macrophages induces an immunosuppressive environment that can contribute to an increased burden of senescent cells. Treatment with immunostimulatory anti-PD-L1 antibody enhances the cytotoxic T cell activity and leads to the elimination of p16, PD-L1-positive cells. Our study uncovers a molecular mechanism of p16-dependent regulation of PD-L1 protein stability in senescent cells and reveals the potential of PD-L1 as a target for treating senescence-mediated age-associated diseases.

2024-02-14 | GSE225286 | GEO

p16-dependent upregulation of PD-L1 impairs immunosurveillance of senescent cells [RNA-seq: Lung Alveolar Macrophages]

2024-02-14 | GSE225285 | GEO

Chronic social stress induces p16-mediated senescent cell accumulation in mice

Project description:Chronic social stress induces p16-mediated senescent cell accumulation in mice

| PRJNA1168108 | ENA

Gene expression profile of p16-induced senescence in normal human diploid fibroblasts.

Project description:Transcriptional profiling of p16-induced senescent human diploid fibroblasts compared with proliferating cells. TIG-3 ER-p16 cells (primary normal human diploid fibroblasts expressing a 4-hydroxytamoxifen(4-OHT) regulatable form of human p16) were cultured for 7 days with or without 4-OHT. Total RNA was isolated using TRIzol reagent and were analyzed using the hum

2014-04-10 | E-GEOD-49863 | biostudies-arrayexpress

Characteristics of the senescent cells of the chronic kidney disease in mice

Project description:To investigate the contribution of the senescent cells to the kidney diseases

2022-09-05 | GSE212274 | GEO