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Human nasopharyngeal metagenome

ABSTRACT: Nasal microbial diversity in Australian Indigenous children in relation to Otitis Media

PROVIDER: PRJNA684919 | ENA |

REPOSITORIES: ENA

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			Action	DRS
		Other
	SRR13264800_1.fastq.gz	Fastqsanger.gz
	SRR13264800_2.fastq.gz	Fastqsanger.gz
	SRR13264801_1.fastq.gz	Fastqsanger.gz
	SRR13264801_2.fastq.gz	Fastqsanger.gz

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Associations between IFI44L gene variants and rates of respiratory tract infections during early childhood

Project description:Background: Genetic heterogeneity in the innate immune system may account for variable susceptibility to respiratory tract infections (RTIs) in children. Objective: We aimed to assess the impact of polymorphisms rs273259 and rs1333969 in type I interferon related gene IFI44L on susceptibility to RTIs and acute otitis media in children. Methods: In two prospective, population-based birth cohorts, the FinnBrain Birth Cohort Study and the STEPS Study, IFI44L genotypes for rs273259 and rs1333969 were determined in relation to the development of RTIs until one and two years of age, respectively, and adjusted incidence rate ratios (aIRR) or odds ratios (OR) were calculated. At age 3 months, whole blood transcriptional profiles were analyzed and nasal samples were tested for respiratory viruses in a subset of children. Results: In respiratory virus-positive children at 3 months of age, IFI44L gene variants were associated with decreased expression levels of IFI44L and several other interferon related genes. Conclusions: Variant forms of IFI44L gene were protective against early-childhood RTIs or acute otitis media in two independent birth cohorts, and they attenuated interferon pathway activation by respiratory viruses.

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