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Expression Profiles of HepG2 cells treated with 7 compounds

ABSTRACT: Expression Profiles of HepG2 cells treated with 7 compounds

PROVIDER: PRJNA685039 | ENA |

REPOSITORIES: ENA

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Expression Profiles of HepG2 cells treated with 22 compounds and solvent controls

Project description:The transcriptomics changes induced in the human liver cell line HepG2 by 17 hepatotoxic compounds, 5 non-hepatotoxic compounds and solvent controls after treatment for 24h The study investigated differential gene expression in HepG2 cell line mRNA following 24 hours of exposure to 17 hepatotoxic compounds, 5 non-hepatotoxic compounds and solvent controls. Three biological replicates per compound/solvent. In total 105 arrays .

2014-02-14 | E-GEOD-51952 | biostudies-arrayexpress

Expression Profiles of HepG2 cells treated with 22 compounds and solvent controls

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Expression Profiles of HepG2 cells treated with 7 compounds

Project description:The transcriptomics-based in vitro assay for predicting chemical genotoxicity in vivo published by Magkoufopoulou et al (2012) was validated by the independent study performed in HepG2 cells for which the gene expression data are described here. The data were reanalyzed for the OpenRiskNet project (Horizon2020 EINFRA-22-2016 Programme; Grant Agreement 731075).

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Expression Profiles of HepG2 cells treated with genotoxic and non-genotoxic agents

Project description:The lack of accurate in vitro assays for predicting in vivo toxicity of chemicals together with new legislations demanding replacement and reduction of animal testing has triggered the development of alternative methods. This study aimed at developing a transcriptomics-based in vitro prediction assay for in vivo genotoxicity. The transcriptomics changes induced in the human liver cell line HepG2 by 34 compounds after treatment for 12h, 24h and 48h were used for the selection of gene-sets that can discriminate between in vivo genotoxins (GTX) and in vivo non-genotoxins (NGTX). By combining publicly available results for these chemicals from standard in vitro genotoxicity studies with transcriptomics, we developed several prediction models. These models were validated by means of an additional set of 28 chemicals. The study investigated differential gene expression in HepG2 cell line mRNA following 12 hours of exposure to 34 different compounds and their solvents; 24 and 48 hours of exposure to 62 different compounds and their solvents. Three biological replicates per compound/solvent. In total 560 arrays .

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HepG2 cells exposed to pesticides and related compounds

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2019-06-20 | E-MTAB-3508 | biostudies-arrayexpress

Expression data for HepG2 cells treated with 34 different chemicals

Project description:This study provides an evaluation of changes in gene expression associated with treating human HEPG2 cells with 34 different chemical compounds. Gene expression experiments studies were performed in triplicate (n=3) with the cells for each replicate treated and harvested on separate days. This series is part of a SuperSeries in which human toxicology-relevant cell lines were treated with three doses of 34 chemical compounds (and corresponding vehicle controls) for 6 hours. Each compound/vehicle treatment group was an individual study performed at different times. Each study was analyzed separately and themes common between studies were reported.

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Expression data for HepG2 cells treated with 34 different chemicals

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