Project description:A new pseudoguaianolide 1 and two new guaiane-type sesquiterpene glucosides 2 and 3, were isolated from the aerial parts of Ambrosia artemisiifolia L together with two known sesquiterpene dilactones 4 and 5. The new compounds were determined on the basis of spectroscopic and chemical methods to be 3?-acetoxy-4?-hydroxy-1?,7?, 10?,11?H-pseudoguaia-12,8?-olide (1), 1?,7?,9?,10?,13?H-guaia-4(5)-en-12,6?-olide 9-O-?-d-glucoside (2) and 4?-hydroxy-1?,5?,7?,9?H-guaia-10(14),11(13)-dien-12-acid 9-O-?-d-glucoside (3). The isolated compounds were evaluated for cytotoxicity against human promyelocytic leukemia HL-60 cell lines in vitro, but were all inactive.
