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Integrated miRNA-mRNA transcriptomic analysis reveals antler growth regulatory network [miRNA-seq]

ABSTRACT: Integrated miRNA-mRNA transcriptomic analysis reveals antler growth regulatory network [miRNA-seq]

PROVIDER: PRJNA685875 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR13264656.fastq.gz	Fastqsanger.gz
	SRR13264657.fastq.gz	Fastqsanger.gz
	SRR13264658.fastq.gz	Fastqsanger.gz
	SRR13264659.fastq.gz	Fastqsanger.gz

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Integrated miRNA-mRNA transcriptomic analysis reveals antler growth regulatory network.

Project description:Integrated miRNA-mRNA transcriptomic analysis reveals antler growth regulatory network.

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Integrated miRNA-mRNA transcriptomic analysis reveals antler growth regulatory network [miRNA-seq]

Project description:As the only regenerative organ of mammals, antler could grow rapidly without carcinogenesis. To understand the molecular mechanisms of the growth of sika deer antler, we used de novo RNA-seq analyses to determine the diﬀerential expression of unigenes and miRNAs from antler at 15, 60, 90, and 110-day. A total of 55004 unigenes, 208 known miRNAs and 38 novel miRNAs were identified. 10182 unigenes and 35 miRNAs were differentially expressed between 60-day and 15-day antler, 13258 unigenes and 53 miRNAs were differentially expressed between 90-day and 60-day antler, and 10740 unigenes and 27 miRNAs were differentially expressed between 110-day and 90-day antler. GO and KEGG analyses showed that DE unigenes and miRNA were mainly related to chondrogenesis, osteogenesis and inhibition of oncogenesis, that were closely associate with antler growth. We also constructed mRNA-mRNA and miRNA-mRNA interaction networks related to chondrogenesis, osteogenesis and inhibition of oncogenesis of antler. The results showed that mRNA (COL2A1, SOX9, WWP2, FGFR1, SPARC, LOX etc.) and miRNAs (miR-145, miR-199a-3p, miR-140, miR-199a-5p etc.) may play important roles in chondrogenesis and osteogenesis of antler, and mRNA (TP53, Tpm3 and ATP1A1 etc.) and miRNAs (miR-106a, miR-145, miR-1260b and miR-2898 etc.) may have key roles in inhibiting the carcinogenesis of antlers. In this study, we identified miRNAs and unigenes related to chondrogenesis, osteogenesis and inhibition of oncogenesis of antler. This will provide a reference for in-depth analysis of the molecular mechanism of antler growth without carcinogenesis, and also provide valuable information for cartilage- and bone-related disease treatment, cancer treatment.

2020-12-17 | GSE163383 | GEO

Integrated miRNA-mRNA transcriptomic analysis reveals antler growth regulatory network [RNA-seq]

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Integrated miRNA-mRNA transcriptomic analysis reveals antler growth regulatory network [RNA-seq]

Project description:Integrated miRNA-mRNA transcriptomic analysis reveals antler growth regulatory network [RNA-seq]

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Integrated miRNA-mRNA transcriptomic analysis reveals antler growth regulatory network.

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-12-17 | GSE163385 | GEO

Integrated Transcriptomic Analysis of the miRNA-mRNA Interaction Network in Thin Endometrium [miRNA-seq]

Project description:Integrated Transcriptomic Analysis of the miRNA-mRNA Interaction Network in Thin Endometrium [miRNA-seq]

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Project description:Although the thin endometrium (TE) has been widely recognized as a critical factor in implantation failure, the contribution of miRNA-mRNA regulatory network to the development of disease aetiology remains to be further elucidated. This study performed an integrative analysis of the miRNA-mRNA expression profiles in the thin and adjacent normal endometrium of 8 patients with intrauterine adhesion to construct the transcriptomic regulatory networks. A total of 1093 differentially expressed genes (DEGs) and 72 differentially expressed miRNAs (DEMs) were identified in the thin adhesive endometrium of the TE group compared with the control adjacent normal endometrial cells. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses showed that DEGs and the target genes of DEM were significantly enriched in angiogenesis, cell growth regulation and Wnt signalling pathway. Multiple hub genes (CAV1, MET, MAL2, has-mir-138, ARHGAP6, CLIC4, RRAS, AGFG1, has-mir-200, and has-mir-429) were identified by constructing the miRNA-mRNA regulatory networks. Furthermore, a miRNA-mRNA-pathway-function analysis was conducted, and the hub genes were enriched in the FoxO signalling pathway, cell growth regulation, inflammatory response regulation and regulation of autophagy pathways. Our study is the first to perform integrated mRNA-seq and miRNA-seq analyses in the thin adhesive endometrium and the control adjacent normal endometrial cells. This study provides new insights into the molecular mechanisms underlying the formation of thin endometrium.

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Project description:Integrated Transcriptomic Analysis of the miRNA-mRNA Interaction Network in Thin Endometrium [RNA-Seq]

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