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SUM159 cells treated with sudemycin D6 (SD6)

ABSTRACT: SUM159 cells treated with sudemycin D6 (SD6)

PROVIDER: PRJNA686066 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR13267490_1.fastq.gz	Fastqsanger.gz
	SRR13267490_2.fastq.gz	Fastqsanger.gz
	SRR13267491_1.fastq.gz	Fastqsanger.gz
	SRR13267491_2.fastq.gz	Fastqsanger.gz
	SRR13267492_1.fastq.gz	Fastqsanger.gz

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MDA-MB-231-LM2 cells treated with sudemycin D6 (SD6)

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SUM159 cells treated with sudemycin D6 (SD6)

Project description:The objective is to identify gene expression patterns that occur after spliceosome inhibition in triple-negative breast cancer.

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Transcriptomic expression of SUM159 cells treated with palbociclib and indisulam

Project description:Transcriptomic expression of SUM159 cells treated with palbociclib and indisulam

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Transcriptomic expression of SUM159 cells treated with palbociclib and indisulam

Project description:Inducing senescence in cancer cells is emerging as a new therapeutic strategy. We tested the senescence induction of palbociclib and indisulam in SUM159 cells, and profiled these for senescence associated gene signatures.

2022-03-03 | GSE197601 | GEO

MDA-MB-231-LM2 cells treated with sudemycin D6 (SD6)

Project description:The objective is to identify gene expression patterns that occur after spliceosome inhibition in triple-negative breast cancer.

2020-12-18 | GSE163411 | GEO

SUM159 cells treated with H3B-8800 or DMSO, Cytoplasmic fraction RNA-seq

Project description:SUM159 cells treated with H3B-8800 or DMSO, Cytoplasmic fraction RNA-seq

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Transcriptomic expression of A549 and SUM159 cells treated with palbociclib and indisulam

Project description:Transcriptomic expression of A549 and SUM159 cells treated with palbociclib and indisulam

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SUM159 cells treated with H3B-8800 or DMSO, J2 enrichment for dsRNA

Project description:SUM159 cells treated with H3B-8800 or DMSO, J2 enrichment for dsRNA

| PRJNA685161 | ENA

Modulation of SF3B1 causes global intron retention and downregulation of the B-cell receptor pathway in chronic lymphocytic leukemia

Project description:Splicing factor SF3B1 is frequently mutated in chronic lymphocytic leukemia (CLL) patients and has been suggested as a potential therapeutic target. In this study, we performed RNA-seq analysis to evaluate the global impact of SF3B1 modulator sudemycin D6 (SD6) on alternative splicing. Our analysis revealed significant increases in global intron-retention in SD6-treated CLL cells. Pathway analysis of the genes associated with increased intron-retention suggested that B-cell receptor (BCR), protein ubiquitination, and PI3K signaling pathways were among the top canonical pathways being affected by SD6. The increases in intron-retention were inversely correlated with deceases in mRNA and protein levels of the affected BCR/PI3K pathway molecules such as BLNK, BTK, AKT1, PLCγ2 and PI3Kδ. SD6 also induced a time-dependent exon-skipping event in mRNA of MCL1 and resulted in significant down-regulation of another anti-apoptotic gene TRAF1, which may contribute to the SD6-induced apoptosis. Finally, SD6 can overcome the pro-survival and pro-growth signals and synergize with ibrutinib, idelalisib and venetoclax to induce apoptosis in primary CLL cells co-cultured with bone marrow stromal cells and in the presence of T-cell-derived cytokines. Cumulatively, these results provide a strong rationale for future clinical development of spliceosome modulators and combinatory therapies based on spliceosome modulators in CLL.

2018-05-17 | GSE114514 | GEO

RNA-Seq analysis of SUM159 DAPK3 knockout (KO) cells and control cells

Project description:We conducted RNA sequencing of SUM159 DAPK3 KO and control cells followed by Gene Set Enrichment Analysis (GSEA) to identify altered gene expression pathways by DAPK3 knockout. Epithelial-mesenchymal transition (EMT) pathway was the top significantly down-regulated pathway in SUM159 DAPK3 KO cells as compared to control cells.

2024-10-10 | GSE273142 | GEO

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