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Developmental programs in neuroblastoma [RNA-seq SK-N-BE(2)C ATRA]

ABSTRACT: Developmental programs in neuroblastoma [RNA-seq SK-N-BE(2)C ATRA]

PROVIDER: PRJNA686094 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR13268234_1.fastq.gz	Fastqsanger.gz
	SRR13268234_2.fastq.gz	Fastqsanger.gz
	SRR13268235_1.fastq.gz	Fastqsanger.gz
	SRR13268235_2.fastq.gz	Fastqsanger.gz
	SRR13268236_1.fastq.gz	Fastqsanger.gz

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Developmental programs in neuroblastoma [RNA-seq SK-N-BE(2)C ATRA]

Project description:Neuroblastoma is a pediatric tumor of the developing sympathetic nervous system. We investigate developmental origins of neuroblastoma, the role of oncogenic MYCN in blocking normal differentiation and evaluate therapeutic interventions to overcome differentiation blocks. Here, we provide expression profiles of SK-N-BE(2)C cells upon treatment with ATRA or solvent control.

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Project description:Neuroblastoma is a pediatric tumor of the developing sympathetic nervous system. We investigate developmental origins of neuroblastoma, the role of oncogenic MYCN in blocking normal differentiation and evaluate therapeutic interventions to overcome differentiation blocks. Here, we provide single cell expression profiles of IMR5/75-shMYCN cells upon knockdown of MYCN and control.

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Human neuroblastoma cell lines: control vs treated with verlindamycin and ATRA

Project description:Analysis of differential gene expression in response to treatment of neuroblastoma cell lines (MYCN-amplified SK-N-BE(2)-C and non-amplified SKNAS) with retinoic acid and verlindamycin (a novel polyamine analogue and LSD1 inhibitor). This compound combination was found efficient in inducing differentiation in neuroblastoma cell lines and the goal of this microarray experiment was to analyse which genes and pathways were altered upon this treatment.

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