Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

The human brain vasculature at single-cell resolution

ABSTRACT: The human brain vasculature at single-cell resolution

PROVIDER: PRJNA686798 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR13278437_1.fastq.gz	Fastqsanger.gz
	SRR13278437_2.fastq.gz	Fastqsanger.gz
	SRR13278438_1.fastq.gz	Fastqsanger.gz
	SRR13278438_2.fastq.gz	Fastqsanger.gz
	SRR13278439_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 50

Similar Datasets

Single-cell dissection of the human brain vasculature

Project description:Single-cell dissection of the human brain vasculature

| PRJNA726925 | ENA

Single-cell atlas of the human brain vasculature across development, adulthood and disease (Extra Individuals)

Project description:A broad range of brain pathologies critically relies on the vasculature, and cerebrovascular disease is a leading cause of death worldwide. However, the cellular and molecular architecture of the human brain vasculature remains incompletely understood. Here, we performed single-cell RNA sequencing of 606,380 freshly isolated endothelial, perivascular and other tissue-derived cells from 117 samples, from 68 human fetuses and adult patients to construct a molecular atlas of the developing fetal, adult control and diseased human brain vasculature. We uncover extensive molecular heterogeneity of the vasculature of healthy fetal and adult human brains and across eight vascular-dependent Central Nervous System (CNS) pathologies including brain tumors and brain vascular malformations. We identify alteration of arteriovenous differentiation and reactivated fetal as well as conserved dysregulated genes and pathways in the diseased vasculature. Pathological endothelial cells display a loss of CNS-specific properties and reveal an upregulation of MHC class II molecules, indicating atypical features of CNS endothelial cells. Cell-cell interaction analyses predict numerous endothelial-to-perivascular cell ligand-receptor crosstalk including immune-related and angiogenic pathways, thereby unraveling a central role for the endothelium within brain neurovascular unit signaling networks. Our single-cell brain atlas provides insight into the molecular architecture and heterogeneity of the developing, adult/control and diseased human brain vasculature and serves as a powerful reference for future studies

2024-02-29 | GSE256491 | GEO

Single-cell atlas of the human brain vasculature across development, adulthood and disease (scRNA-Seq)

2024-02-29 | GSE256490 | GEO

Single-cell atlas of the human brain vasculature across development, adulthood and disease (bulk RNA-Seq)

2024-02-29 | GSE256492 | GEO

Single-cell dissection of the human brain vasculature

Project description:Here, we perform the first single-cell characterization of the human cerebrovasculature using both ex vivo fresh tissue experimental enrichment and post mortem in silico sorting of human cortical tissue samples. We capture 16,681 cerebrovascular nuclei across 11 subtypes, including endothelial cells, mural cells, and three distinct subtypes of perivascular fibroblasts along the vasculature. We uncover human-specific expression patterns along the arteriovenous axis and determine previously uncharacterized cell type-specific markers. We use our newly discovered human-specific signatures to study changes in 3,945 cerebrovascular cells of Huntington’s disease patients, which reveal an activation of innate immune signaling in vascular and glial cell types and the concomitant reduction to proteins critical for maintenance of blood-brain barrier integrity. Finally, our study provides a comprehensive resource molecular atlas of the human cerebrovasculature to guide future biological and therapeutic studies.

2022-02-11 | GSE173731 | GEO

Single-cell atlas of the human brain vasculature across development, adulthood and disease

Project description:Single-cell atlas of the human brain vasculature across development, adulthood and disease

| PRJNA1079773 | ENA

The human brain vasculature at single-cell resolution

Project description:10x single-cell RNA-sequencing to profile human cerebrovascular cells in health and disease

2021-04-24 | GSE163577 | GEO

The Drosophila Brain on Cocaine at Single Cell Resolution

Project description:The Drosophila Brain on Cocaine at Single Cell Resolution

| PRJNA639538 | ENA

Transcriptome map of the human brain at the single-cell resolution

Project description:Transcriptome map of the human brain at the single-cell resolution