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LncRNA CHROME regulates the interferon response to viral and bacterial challenge [RNA-Seq]

ABSTRACT: LncRNA CHROME regulates the interferon response to viral and bacterial challenge [RNA-Seq]

PROVIDER: PRJNA686957 | ENA |

REPOSITORIES: ENA

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LncRNA CHROME regulates the interferon response to viral challenge

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LncRNA CHROME regulates the interferon response to viral and bacterial challenge [RNA-Seq]

Project description:Long non-coding RNAs (lncRNAs) are important regulators of the immune response. Here we identify a novel function for the primate-specific lncRNA, CHROME. We established that CHROME is most highly transcribed in human macrophages treated with bacterial lipopolysaccharide and RNA viruses.

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LncRNA CHROME regulates the interferon response to viral challenge

Project description:This SuperSeries is composed of the SubSeries listed below.

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Expression analysis of genes modulated after knock-down of lncRNA CHROME.

Project description:Thousands of long non-coding RNAs (lncRNAs) have been identified in the human genome, many of which are not conserved in lower mammals. The majority of these lncRNAs remain functionally uncharacterized and may have important implications in human physiology and disease. Here, we identify a primate-specific lncRNA, CHROME, which is increased in the plasma and atherosclerotic plaques of individuals with coronary artery disease compared to healthy controls. Using a loss-of-function approach, we show that CHROME functions as a competing endogenous RNA of microRNAs and regulates the concentration and biological functions of target genes.

2018-09-20 | GSE97469 | GEO

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