Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Chip-seq, ATAC-seq, and RNA-seq of murine P14 T cells WT or FOXO1 KO, responding in vivo to LCMV-ARM

ABSTRACT: Chip-seq, ATAC-seq, and RNA-seq of murine P14 T cells WT or FOXO1 KO, responding in vivo to LCMV-ARM

PROVIDER: PRJNA687259 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR13290100.fastq.gz	Fastqsanger.gz
	SRR13290101.fastq.gz	Fastqsanger.gz
	SRR13290102.fastq.gz	Fastqsanger.gz
	SRR13290103.fastq.gz	Fastqsanger.gz
	SRR13290104.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 65

Similar Datasets

Chip-seq, ATAC-seq, and RNA-seq of murine P14 T cells WT or FOXO1 KO, responding in vivo to LCMV-ARM

Project description:P14 CD8+ murine T cells were adoptively transferred to C57BL/6 hosts and infected with LCMV-ARM. At indicated times post-infection (see sample name), P14 T cells of the indicated cell-surface phenotype were isolated and sujectected to ChIP-seq, RNA-seq or ATAC-seq.

2021-02-19 | GSE163723 | GEO

RNA-seq of P14 CD8 T cells during acute LCMV infection

Project description:We performed RNA-seq, ATAC-seq, and H3K27Ac ChIP-seq on P14 CD8 T cells during acute infection with LCMV Armstrong on days 0 (naïve cells), 9 (memory precursor effector cells (MPEC) and short-lived effector cells (SLECs)), and 40+ (memory cells) post infection.

2021-04-02 | GSE150441 | GEO

ATAC-seq of P14 CD8 T cells during acute LCMV infection

2021-04-02 | GSE150438 | GEO

Expression data from LCMV-infected P14 and Akt transgenic P14 CD8 T cells

Project description:The PI3K/Akt signaling pathway impacts various aspects of CD8 T cell homeostasis, such as effect versus memory cell differentiation, during viral infection. We used microarrays to determine which downstream molecules were affected and what other signaling pathways were interconnected with the Akt pathway by constitutive activation of Akt in LCMV-infected CD8 T cells. Splenocytes from naive P14/WT or P14/Akt mice were stained with anti-CD8 and anti-Ly5.1, and CD8 T cells were sorted using a FACSAria II instrument. Purified Ly5.1+ CD8 T cells from P14/WT or P14/Akt mice were transferred into B6 mice, which were subsequently infected with LCMV Armstrong. At day 8 post infection, splenocytes were stained with anti-CD8, anti-Ly5.1, anti-KLRG1, and anti-CD127. Following staining, short-lived effector cells (SLECs) and memory precursor effector cells (MPECs) were sorted using the FACSAria II instrument; the purity of the sorted cells was >95%. A total of 5 samples were analyzed, including WT naive, WT SLEC, WT MPEC, Akt naive and Akt SLEC.

2012-03-01 | E-GEOD-36168 | biostudies-arrayexpress

H3K27Ac ChIP-seq of P14 CD8 T cells during acute LCMV infection

2021-04-02 | GSE150440 | GEO

RNA-seq of LCMV GP33-specific CD8 TCR transgenic cells (P14) primed at the onset versus in the midst of persistent LCMV-Clone 13 viral infection

Project description:Altered CD8 T cell differentiation and functional exhaustion prevent control of chronic virus infection and cancer. Yet, how fate commitment and exhaustion are determined and dynamically modulated throughout persistent infection are unclear. We compared the activation and differentiation of LCMV GP33-specific CD8 TCR transgenic cells (P14) primed at the onset versus in the midst of established persistent LCMV-Clone 13 viral infection. LCMV GP33-specific CD8 TCR transgenic (P14) cells were injected into naïve mice immediately infected with LCMV-Cl13 (Early priming) or into mice that had been infected 21 days earlier with LCMV-Cl13 (Late Priming). Sixty hours post-priming P14 cells were sorted from mice and subjected to RNA seq. We show early primed cells very rapidly exhibit a transcriptional profile of robust activation, effector differentiation and dysfunction, while late primed cells have increased expression of genes involved in memory differentiation and maintenance.

2018-10-09 | GSE105044 | GEO

Gene expression profile of splenic p14 effector T cells eight days after LCMV infection

Project description:Microarray analyses was employed to determine the gene expression profiles of LCMV-specific p14 CD8+ effector T cells eight days after an acute LCMV Armstrong infection providing a framework to compare and contrast effector function potential of distinct immune cell subsets to CD8+ effector T cells.

2015-06-01 | GSE44410 | GEO

ATAC-seq of P14 CD8 T cells during acute LCMV infection

Project description:ATAC-seq of P14 CD8 T cells during acute LCMV infection

| PRJNA632040 | ENA

RNA-seq of P14 CD8 T cells during acute LCMV infection

Project description:RNA-seq of P14 CD8 T cells during acute LCMV infection

| PRJNA632046 | ENA

P14 CD8 T cells during acute LCMV infection

Project description:P14 CD8 T cells during acute LCMV infection

| PRJNA632045 | ENA