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Chromatin accessibility analysis of CNS4-sufficient and defincient regulatory T cells, Treg cell precursors, and mature and semimature CD4 single positives

ABSTRACT: Chromatin accessibility analysis of CNS4-sufficient and defincient regulatory T cells, Treg cell precursors, and mature and semimature CD4 single positives

PROVIDER: PRJNA687668 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR13301900_1.fastq.gz	Fastqsanger.gz
	SRR13301900_2.fastq.gz	Fastqsanger.gz
	SRR13301901_1.fastq.gz	Fastqsanger.gz
	SRR13301901_2.fastq.gz	Fastqsanger.gz
	SRR13301902_1.fastq.gz	Fastqsanger.gz

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Chromatin accessibility analysis of CNS4-sufficient and defincient regulatory T cells, Treg cell precursors, and mature and semimature CD4 single positives

Project description:We have discovered that deletion of a conserved regulatory element upstream of the Foxp3 gene, termed CNS4, results in the abrogation of IL-2 mediated induction of Foxp3 expression during regulatory T cell development. However, the mice still harbor a reduced but functional population of Treg cells. To understand potential compensatory mechanisms driving the differentiation and expansion of regulatory T cells in the absence of CNS4, we profiled CNS4-deficient and -sufficient regulatory T cells, as well as related cell types, from the thymuses of male mice by ATAC-sequencing.

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