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Mismatch repair protein coordinate with SETD2 to activate DNA oxidative damage response and repair in human cells

ABSTRACT: Mismatch repair protein coordinate with SETD2 to activate DNA oxidative damage response and repair in human cells

PROVIDER: PRJNA688290 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR13314132.fastq.gz	Fastqsanger.gz
	SRR13314133.fastq.gz	Fastqsanger.gz
	SRR13314134.fastq.gz	Fastqsanger.gz
	SRR13314135.fastq.gz	Fastqsanger.gz
	SRR13314136.fastq.gz	Fastqsanger.gz

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Mismatch repair protein coordinate with SETD2 to activate DNA oxidative damage response and repair in human cells

Project description:There is mounting evidence that mismatch repair (MMR) proteins are involved in oxidative DNA damage response. SETD2, the histone H3K36 tri-methyltransferase, is a newly found factor participate in MMR pathway in human cells. In this study, we show that SETD2 can directly interact with MMR protein MutSα, and they are enriched and colocalized in chromatin in response to oxidative damage, which maybe the reason for the amplification of H3K36me3. Moreover, MutSα and SETD2 are essential for ATM and CHK2 activation upon H2O2 treatment, loss of SETD2 and MutSα will display impaired DNA damage response and oxidative DNA repair, which will accumulate oxidative damage and lead to more cell apoptosis and cell death. Our finding provided a novel SETD2 dependent mechanism for the oxidative DNA damage response together with MMR protein.

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