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ABSTRACT: Single cell RNA Sequencing of term Umbilical cord blood mononuclear cells

PROVIDER: PRJNA690128 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR13375249.fastq.gz	Fastqsanger.gz
	SRR13375250.fastq.gz	Fastqsanger.gz
	SRR13375251.fastq.gz	Fastqsanger.gz
	SRR13375252.fastq.gz	Fastqsanger.gz
	SRR13375253.fastq.gz	Fastqsanger.gz

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EPC senescence

Project description:Transcription profiling of human umbilical cord blood derived Outgrowth Endothelial Cells (OECs) at early and late passages. Outgrowth endothelial cells were isolated from the mononuclear fraction of umbilical cord blood and cultured on collagen coated flasks. Once OEC colonies emerged they were expanded in culture to study cell growth kinetics. Total RNA was extracted from OECs at an early passage and OECs at a late passage which were becoming senescent . The purpose of this experiment was to were compared early and late passage OECs to determine how senescence affects the gene expression profile of OECs.

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Project description:RNA sequencing of cord blood mononuclear cells

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Neonatal and adult platelet proteomics

Project description:We isolated resting platelets from full term umbilical cord blood and adult peripheral blood. We used DIA mass spectrometry to analyze the whole proteome and phosphoproteome from this platelet samples.

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Single-cell immunophenotyping of the fetal immune response to maternal SARS-CoV-2 infection

Project description:During the COVID-19 pandemic, thousands of pregnant women have been infected with SARS-CoV-2 worldwide. The short- and long-term implications of maternal SARS-CoV-2 infection on fetal and childhood well-being are unknown. To characterize the fetal immune response to maternal SARS-CoV-2 infection, we performed single-cell RNA sequencing and T cell receptor sequencing on cord blood mononuclear cells from infants born to mothers infected with SARS-CoV-2 in the third trimester. We identified widespread gene expression changes in cord blood leukocytes, including upregulation of interferon-stimulated genes (ISG) and of HLA genes in CD14+ monocytes; decreased activation of CD16+ monocytes; activation of plasmacytoid dendritic cells; and activation and exhaustion of NK cells and T CD8+ cells in the cord blood of infants born to SARS-CoV-2+ mothers. Lastly, we observed fetal TCR repertoire clonal expansion in cord blood T cells from pregnancies complicated by maternal SARS-CoV-2 infection. Our results suggest that even in the absence of vertical transmission, SARS-CoV-2 maternal infection in the third trimester modulates the fetal immune system.

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