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Transcriptome profiling of wild-type (WT) and USP8 knockout (KO) CT26 cell lines

ABSTRACT: Transcriptome profiling of wild-type (WT) and USP8 knockout (KO) CT26 cell lines

PROVIDER: PRJNA691207 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR13402386.fastq.gz	Fastqsanger.gz
	SRR13402387.fastq.gz	Fastqsanger.gz
	SRR13402388.fastq.gz	Fastqsanger.gz
	SRR13402389.fastq.gz	Fastqsanger.gz
	SRR13402390.fastq.gz	Fastqsanger.gz

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Transcriptome profiling of wild-type (WT) and USP8 knockout (KO) CT26 cell lines

Project description:USP8 is one of DUBs and is frequently overexpressed or gain-of-function mutated in multiple types of human cancer. Importantly, USP8 has been identified as an immunomodulatory DUB as T cell-specific Usp8 deficiency disrupts regulatory T cell functions, leading to recruiting abundant CD8+ T cells in colons and resulting in the inflammatory bowel disease in mice. However, whether targeting USP8 can enhance anti-tumor immunity has not been reported. To further explore the physiological function of USP8, we performed the transcriptomic analysis to comprehensively understand which signaling pathways are mainly regulated by USP8 in cancer cells. Usp8 WT and KO CT26 cells were harvested for RNA-sequencing (RNA-seq).

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RNA sequencing of mouse CT26 knockout Pd-l1 cells rescued with WT or K262Q Pd-l1

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Genome-wide maps of chromatin state in WT and Whsc1 ko or Nlrc5 ko CT26 cells.

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