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Single-cell RNAseq analysis of CaCl2-induced mouse abdominal aortic aneurysm (AAA) samples

ABSTRACT: Single-cell RNAseq analysis of CaCl2-induced mouse abdominal aortic aneurysm (AAA) samples

PROVIDER: PRJNA691545 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR13417503_1.fastq.gz	Fastqsanger.gz
	SRR13417503_2.fastq.gz	Fastqsanger.gz
	SRR13417504_1.fastq.gz	Fastqsanger.gz
	SRR13417504_2.fastq.gz	Fastqsanger.gz
	SRR13417505_1.fastq.gz	Fastqsanger.gz

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RNA-sequencing of abdominal aortic aneurysm (AAA) and control abdominal aorta tissues

Project description:Abdominal aortic aneurysm (AAA) is a permanent segmental dilatation of the abdominal aorta, contributing to a high mortality once rupture. We performed RNA-sequencing analysis of abdominal aorta tissues from 14 participants, including seven patients with AAA and seven control individuals.

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Single-cell RNAseq analysis of CaCl2-induced mouse abdominal aortic aneurysm (AAA) samples

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Project description:We sought to identify differentially regulated microRNAs in infrarenal mouse aortic tissue after AAA-induction with PPE, compared with sham-operated mice. This treatment leads to rapid development of infrarenal aortic aneurysms with significant diameter differences observed by Day 7. We found 41 miRNAs were up-regulated with aneurysm and 37 down-regulated at p<0.05, which were also altered by >1.5-fold. Utilizing the PPE infusion model, we induced AAA in Male 10-week-old C57/Bl6 mice, 7 days after AAA-induction with PPE. One array per mouse, 5 mice per group, two groups (PPE and sham).

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