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Transcriptomic alterations upon HSP90 inhibition in human LN229 and T98 glioblastoma cells in vitro

ABSTRACT: Transcriptomic alterations upon HSP90 inhibition in human LN229 and T98 glioblastoma cells in vitro

PROVIDER: PRJNA691626 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR13423200.fastq.gz	Fastqsanger.gz
	SRR13423201.fastq.gz	Fastqsanger.gz
	SRR13423180.fastq.gz	Fastqsanger.gz
	SRR13423181.fastq.gz	Fastqsanger.gz
	SRR13423182.fastq.gz	Fastqsanger.gz

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Transcriptomic alterations upon HSP90 inhibition in human LN229 and T98 glioblastoma cells in vitro

Project description:Purpose: Characterization of transcriptomic alterations upon HPS90 inhibition in human LN229 and T98G glioblastoma cells in vitro. Methods: LN229 and T98G glioblastoma cells were treated with 10 nM of the HSP90 inhibitor NW457 or the vehicle control for 24 h, and total RNA was subjected to 3' RNA sequencing. Results: Distinct transcriptomic alterations were observed, dominated by a transcriptional upregulation of the heat shock response. Conclusion: HSP90 inhibition resulted in distinct transcriptomic alterations and a clear upregulation of the heat shock response.

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Project description:Overexpression of miR-127-3p in LN229 glioblastoma cells promotes their migration and invasion in vitro and in vivo in xenograft models. We used microarrays to detail the global programme of gene expression in miR-127-3p overexpression LN229 cells compared with mock overexpression LN229 cells MiR-127-3p overexpression LN229 cells and and mock overexpression LN229 cells were cultured in DMEM cell culture media for RNA extraction and hybridization on Affymetrix microarrays. We sought to obtain the genes regulated by miR-127-3p in glioblastoma cell lines.

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